多磺酸粘多糖乳膏联合丁酸氢化可的松乳膏治疗婴儿湿疹的疗效观察

Clinical Observation of Mucopolysaccharide Polysulfate Cream Combined With Hydrocortisone Ointment Butyrate in the Treatment of Infantile Eczema

目的:观察多磺酸粘多糖乳膏联合丁酸氢化可的松乳膏外用治疗婴幼儿湿疹的临床疗效及安全性。方法:治疗组多磺酸粘多糖乳膏联合丁酸氢化可的松乳膏涂于患处;对照组仅外用丁酸氢化可的松乳膏涂于患处,每天早晚各一次。用药7 d、14 d及痊愈后2周分别记录皮疹情况。结果:治疗组、对照组各观察60例,痊愈率分别为81.67%、63.33%;总有效率分别为90.00%、75.00%,治疗组疗效优于对照组,且起效时间较对照组短,复发率低,差异有统计学意义(P<0.05)。结论:多磺酸粘多糖乳膏联合丁酸氢化可的松乳膏外用治疗婴幼儿湿疹疗效肯定,起效时间短,安全性高,复发率低。

Objectve：To evaluate the efficacy and safety of mucopolysaccharide polysulfate cream combined with hydrocortisone oint -ment butyrate in the treatment of infantile eczema.Methods：A randomized controlled open trial was performed.The treatment group was ap-plied with mucopolysaccharide polysulfate cream once every morning and hydrocortisone ointment butyrate once every night alternatively .The control group was treated with hydrocortisone ointment butyrate twice per day only.The variations of the rash were recorded and evaluated in the return visit of 7,14 days after medication and 2 weeks after recovery.Results：60 patients were equally enrolled into each group ,the cure rate with 81.67%、63.33%;and total effective rate with 90.00%、75.00%, which the treament group were significantly higer than those in control group.Also the treatment group had advantages to control group in recurrence rate and the time of producing effectiveness.Conclusion：The combined treament of mucopolysaccharide polysulfate cream with hydrocortisone ointment butyrate in infan -tile eczema is a very effective and safe way.