孟鲁司特钠联合丙卡特罗治疗小儿慢性咳嗽的临床效果观察

Clinical effect observation of montelukast soudium combined with procaterol in the treatment of chronic cough in children

目的：探讨孟鲁司特钠联合丙卡特罗治疗小儿慢性咳嗽的临床效果。方法选取本院2013年1月～2014年1月收治的100例小儿慢性咳嗽患者，将其随机分为观察组与对照组，每组各50例。对照组给予丙卡特罗治疗，观察组在对照组的基础上给予孟鲁司特钠治疗，比较两组的治疗效果。结果观察组的总有效率为96%，明显高于对照组的68%，差异有统计学意义（P＜0.05）。观察组咳嗽缓解时间、咳嗽消失时间均短于对照组（P＜0.05）。两组治疗前血清IgE水平比较差异无统计学意义（P＞0.05）。两组治疗后血清IgE水平较治疗前均下降，观察组下降幅度较对照组显著（P＜0.05）。两组均无严重不良反应发生。结论孟鲁司特钠联合丙卡特罗治疗小儿慢性咳嗽具有较高的安全性和有效性。

Objective To explore the clinical effect of montelukast soudium combined with procaterol in the treatment of chronic cough in children. Methods 100 pediatric patients with chronic cough treated in our hospital from January 2013 to January 2014 were selected and randomly divided into observation group and control group,each group of 50 cases.The procaterol was used in control group,on the basis of control group,montelukast soudium was applied in obser-vation group.The therapeutic effect in both groups was compared. Results Total effective rate in observation group was 96%,significantly higher than that in control group （68%）,with statistical difference （P〈0.05）.The cough relieving time and cough disappearing time in observation group was shorter than that in control group respectively（P〈0.05）.There was no statistical difference in serum IgE before treatment between two groups （P〉0.05）.After treatment,the level of serum IgE in two groups was decreased than that before treatment respectively,observation group decreased significantly com-pared with control group（P〈0.05）.No severe adverse reaction occurred in both groups. Conclusion Montelukast soudium combined with procaterol in the treatment of chronic cough in children has a high safety and effectiveness.