氯胺酮相关性膀胱炎3例报告并文献复习

Report on 3 cases of ketamine associated cystitis and review of literature

目的：分析3例氯胺酮相关性膀胱炎的临床表现、诊断、治疗，以提高对该病的确诊率及疗效。方法对2012年8月~2013年10月本科收治的3例氯胺酮相关性膀胱炎患者进行分析并对相关文献进行复习。结果尿频、尿急、尿痛伴或不伴下腹部、盆腔疼痛或血尿为氯胺酮相关性膀胱炎的主要症状，膀胱容量变小、膀胱壁增厚或可伴有上尿路积水为主要改变，戒食氯胺酮及碱化利多卡因结合膀胱水扩张等综合治疗为主要方法。结论对不明原因明显下尿路症状而治疗效果不佳的年轻患者，应考虑氯胺酮相关性膀胱炎的可能，系统追问病史有助于诊断，多手段综合治疗对缓解症状有明显疗效。

Objective To analyse clinical manifestation,diagnosis,treatment on 3 cases of ketamine associated cystitis in order to improve the diagnosis rate and curative effect of the disease. Methods The data of 3 patients with ketamine associated cystitis treated in our department from August 2012 to October 2013 were analysed and associated litera-tures were reviewed. Results The main symptoms of ketamine associated cystitis were urinary frequency,urgency,urinary pain with or not with lower abdomen.The main pathological changes of ketamine associated cystitis included the smaller bladder capacity,bladder wall thickening or may be associated with upper tract water.The comprehensive treatments in-cluding quit eating ketamine and alkalinization lidocaine combined with bladder water expansion were main methods. Conclusion Young patients with under the unknown causes,obvious urinary tract symptoms and poor treatment effect should consider the possibility of ketamine correlation cystitis.System ask of history is helpful to the diagnosis.Multiple means and integrated treatments have obvious curative effect on the remission of symptoms.