间充质干细胞临床应用的安全性问题

Security problem on clinical application of mesenchymal stem cells

间充质干细胞是干细胞家族的重要成员,起源于中胚层和外胚层,因其具有易分离、趋化性、免疫调节作用、多向分化潜能等生物学特性而日益受到人们的关注,并成为细胞疗法中治疗各种难治性疾病的热门种子细胞,然而细胞疗法所涉及的潜在风险还不确定。本文就间充质干细胞应用所涉及的安全性问题作综述,并强调建立规范化的应用标准更有利于细胞产品在临床上的应用和推广,给广大患者带来真正的福音。

Mesenchymal stem cells（MSCs）are of the important members of the family of stem cells,derived from meso-derm and ectoderm.Because of biological characteristics such as easy separation,chemotaxis,immune regulation,multiple differentiation potention and so on,MSCs are becoming more and more attention.In cell therapy,MSCs become popular seed cells in the treatment of various refractory disease.However,the potential risk involved in cell therapy is uncertain. In this paper,security issues involved about MSCs application are summarized.Emphasis on establishing standardized application standards are more conducive to cell products in clinical application and popularization,which give the ma-jority of patients to bring the true gospel.