法舒地尔对慢性肺源性心脏病血浆硫化氢和N末端B型脑钠肽的影响

The influence of fasudil on plasma H2 S and NT-proBNP in patients with chronic pulmonary heart disease

目的：探讨法舒地尔对慢性肺源性心脏病血浆硫化氢（H2S）和N末端B型脑钠肽（NT-proBNP）的影响。方法102例慢性肺心病患者按照数字表法随机分为观察组和对照组，各51例。对照组采用常规治疗，观察组在常规治疗的基础上加用法舒地尔，两组共治疗14 d。治疗前后测定患者的平均肺动脉压力（MPAP），血浆H2S和NT-proBNP。结果治疗后观察组总有效率为96．1％，高于对照组的86．3％（χ2＝4.046，P＜0．05）。两组治疗后MPAP均明显下降，且观察组比对照组下降更明显（t＝7．246，P＜0．05）。治疗后两组血浆H2S均有明显升高，且观察组升高更明显（t＝2．856，P＜0．05），两组治疗后血浆NT-proBNP均有明显降低，且观察组降低更明显（t＝10．706，P＜0．05）。结论法舒地尔可以明显改善慢性肺源性心脏病患者血浆H2 S和NT-proBNP。

Objective To explore the influence of fasudil on plasma hydrogen sulfide（H2S）and N-terminal B-type natriuretic peptide（ NT-proBNP） in patients with chronic pulmonary heart disease.Methods According to the digital table,102 patients with chronic pulmonary heart disease were randomly divided into the observation group and the control group, each group in 51 cases.The patients in the control group were treated through the conventional treatment,while the patients in the observation group were treated through the conventional treatment plus fasudil. They were treated for 14 days.The mean pulmonary artery pressure（ MPAP） ,plasma H2 S and NT-proBNP were detec-ted.Results After treatment,the total effective rate in the observation group was 96.1%,which was higher than 86.3%in the control group（χ2 =4.046,P〈0.05）.MPAP in the two groups of patients were significantly decreased, and the observation group decreased more significantly than the control group（t=7.246,P〈0.05）.After treatment, plasma H2S were significantly higher,and the observation group increased more significantly（t=2.856,P〈0.05）, plasma NT-proBNP in two groups after treatment were significantly reduced,and the observation group decreased sig-nificantly（t=10.706,P〈0.05）.Conclusion Fasudil can be significantly improved plasma H2S and NT-proBNP in patients with chronic pulmonary heart disease.