心肌炎患儿血清胰岛素样生长因子-1水平变化及意义

Changes and significance of insulin-like growth factor-1 in infant myocarditis

目的：探讨心肌炎患儿血清胰岛素样生长因子-1（IGF-1）水平变化及意义。方法选择50例心肌炎患儿，分别在急性期和恢复期抽取外周静脉血，用于IGF-1和CK-MB测定。选取参加健康体检的婴幼儿50例作为对照。 IGF-1用ELISA法测定， CK-MB 用电-化学发光法测定。结果患儿急性期 IGF-1为（22.90±9．30）mg/L，显著低于对照组及恢复期[（45．69±10．95）mg/L，（38．99±9．06）mg/L，均P＜0．01]， CK-MB为（77．48±8．71）mg/L，显著高于对照组及恢复期[（14．99±7．62）mg/L，（17．99±6．31）mg/L，均P＜0．01]。 IGF-1与CK-MB呈负相关（r＝-0．62，P＜0．01）。结论 IGF-1可能参与心肌炎心肌损伤修复过程，起保护作用。

Objective To investigate insulin-like growth factor-1（IGF-1） on the protective effect of infant myocarditis.Methods The serum levels of IGF-1 was detected by two-site enzyme-linked immunosorbent assy （ ELISA） and CK-MB by electrochemiluminescence at the acute and convalescent in 50 infant with myocarditis,and 50 normal healthy children as the controls.Results The serum levels of IGF-1 in acute myocarditis was significantly lower than those of healthy children and the convalescen[（22.90 ±9.30） mg/L vs （45.69 ±10.95） mg/L, （38.99 ±9.06）mg/L,all P〈0.01],while the CK-MB was significantly higher than those of the control group and the convalescent[（77.48 ±8.71）mg/L vs （14.99 ±7.62）mg/L,（17.99 ±6.31）mg/L,all P〈0.01.IGF-1 and CK-MB was negative correlation （r=-0.62,P〈0.01）.Conclusion IGF-1 is involved in the repair process of myocardial injury in myocarditis infant,and play some protective role in the mechanism.