艾普拉唑治疗十二指肠球部溃疡的疗效观察

The clinical efficacy of ilaprazole in the treatment of duodenal bulb ulcer

目的：比较艾普拉唑和奥美拉唑三联疗法治疗幽门螺杆菌（ Hp ）阳性十二指肠球部溃疡的疗效。方法100例Hp阳性的十二指肠球部溃疡患者采用抽签法随机分为两组，分别给予艾普拉唑或奥美拉唑为基础的三联疗法治疗，5周后复查胃镜和13 C呼气试验，观察Hp根除率、1周和5周症状缓解率、溃疡愈合率和药物不良反应。结果艾普拉唑组和奥美拉唑组的Hp根除率分别为92％、78％（χ^2=3．853，P＜0.05）；溃疡愈合率分别为96％、90％（χ^2=1．561，P＞0．05）；治疗1周症状缓解率分别为92．3％、86．8％（上腹痛），89．7％、73．3％（反酸），88．9％、75．0％（烧灼感）；两组均未发现严重不良反应。结论艾普拉唑＋阿莫西林＋克林霉素三联疗法是根除Hp的理想方案。

Objective To compare the clinical efficacy of ilaprazole standard triple therapy with omeprazole standard triple therapy in the treatment of patients with Helicobacter pylori （ Hp ） positive duodenal bulb ulcer. Methods 100 patients with Hp positive duodenal bulb ulcer were randomly divided into the two groups by lottery, given ilaprazole standard triple therapy and omeprazole standard triple therapy respectively.After 5 weeks of the course,take gastroscopy and the enzyme 13C-urea breath test,and the Hp eradication rate,clinical efficacy,ulcer heal-ing rate and adverse reactions were observed.Results The Hp eradication rate is better than the omeprazole group （92%vs 78%,χ^2=3.853,P〈0.05）,while the ulcer healing rate were no significant （96%vs 90%,χ^2=1.561, P〉0.05）.Conclusion It is a good method in the treatment of Hp positive duodenal bulb ulcer for ilaprazole stand-ard triple therapy.