期刊文献+

慢性肾脏病血管钙化治疗新进展 被引量:7

下载PDF
导出
摘要 血管钙化(Vascular calcification,VC)是慢性肾脏病(chronic kidney disease,CKD)、衰老、动脉粥样硬化、骨质疏松、糖尿病血管病变等疾病发生发展过程中普遍存在的病理生理现象.VC在CKD各个阶段均存在,随着肾功能恶化逐渐加重,CKD5期时达到顶峰.血管钙化是ESRD患者发生心血管事件与死亡的强有力的预测因素,与动脉粥样硬化斑块数量、心肌梗死和心脏骤停等心血管事件关系密切.因此,有效治疗血管钙化对于减少CKD患者心血管事件、改善患者预后具有十分重要的意义.
出处 《中国血液净化》 2014年第9期650-653,共4页 Chinese Journal of Blood Purification
基金 江苏省卫生厅面上科研课题 H200834
  • 相关文献

参考文献36

  • 1Johnson, R.C., J.A. Leopold and J. Loscalzo, Vascular calcification: pathobiologieal mechanisms and clinical implications[J]. Cire Res, 2006, 99: 1044-1059.
  • 2Temmar, M., et al., Pulse wave velocity and vascular calcification at different stages of chronic kidney disease[J]. J Hypertens, 2010, 28: 163-169.
  • 3Mizobuchi, M., D. Towler and E. Slatopolsky, Vascular calcification: the killer of patients with chronic kid- ney disease[J]. J Am Soc Nephrol, 2009, 20: 1453-1464.
  • 4Bostrom, K.I., N.M. Rajamannan and D.A. Towler, The reg- ulation of valvular and vascular sclerosis by osteogen- ic morphogens[J]. Circ Res, 2011, 109: 564-577.
  • 5Schneider, A., et al., Determinants of cardiovascular risk in haemodialysis patients: post hoc analyses of the AURORA study[J]. Am J Nephrol, 2013, 37: 144-151.
  • 6Rangrez, A.Y., et al., Inorganic phosphate accelerates the migration of vascular smooth muscle cells: evi- dence for the involvement of miR- 223[J]. PLoS One, 2012, 7: e47807.
  • 7Ben-Dov, I.Z., et al., The parathyroid is a target or- gan for FGF23 in rats[J]. J Clin Invest, 2007, 117: 4003-4008.
  • 8Stubhs, J.R., et al., Role of hyperphosphatemia and i, 25- dihydroxyvitamin D in vascular calcification and mortality in fihrohlastic growth factor 23 null mice [J]. J Am Soc Nephrol, 2007, 18: 2116-2124.
  • 9Srivaths, P.R., et al., Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodial- ysis patients[J]. Pediatr Nephrol, 2011, 26: 945-951.
  • 10Nasrallah, M.M., et al., Fibrohlast growth factor- 23 (FGF-23) is independently correlated to aortic calcifi- cation in haemodialysis patients[J]. Nephrol Dial Transplant, 2010, 25: 2679-2685.

同被引文献73

引证文献7

二级引证文献54

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部