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UGT1A1基因多态性与伊立替康治疗结直肠癌不良反应的研究现状 被引量:1

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摘要 药物遗传基因组学是结直肠癌个体化治疗领域的研究热点。伊立替康在体内转化为活性成分SN38后主要经UGT1A1解毒成SN38G排出体外。UGT1A1发生*28或*6突变后功能下降,需减少伊立替康剂量以避免毒副反应。
出处 《癌症进展》 2014年第4期323-327,共5页 Oncology Progress
基金 国家自然科学基金项目(81260340)
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