超声导入尿激酶治疗急性下肢深静脉血栓的临床研究

Clinical Study on Therapeutic Effect of Acute Lower Limbs DVT Treated With Urokinase Induced by Ultrasound

目的评价超声导入尿激酶治疗急性下肢深静脉血栓(DVT)的临床疗效及安全性。方法选择60名急性下肢DVT患者随机分成两组各30例,对照组按常规溶栓治疗,治疗组在常规溶栓基础上加用超声导入尿激酶,比较两组的临床疗效。结果治疗组治愈率明显高于对照组(P<0.05),治疗组缓解患肢的肿胀、疼痛所需时间以及D-Dimer水平达峰值所需时间明显少于对照组(P<0.05)。结论超声导入尿激酶配合常规溶栓治疗急性下肢DVT疗效确切,能明显增强溶栓作用,安全、可靠。

Objective To study the safety and clinical therapeutic effect of acute lower limbs deep vein thrombosis （DVT） treated with urokinase induced by ultrasonic phonophoresis. Methods 60 patients with DVT were randomly divided into two groups, with 30 cases in each group. The control group was given routine thrombolytic therapy, while the treatment group was given urokinase induced by ultrasound on the basis of routine thrombolytic therapy. The clinical effect of the two groups was compared. Results The cure rate of the treatment group was significantly higher than that of the control group （P〈0.05）, and the times of relieving swelling and pain, and the time of D-Dimer level at peak were significantly lower than those of the control group （P 〈0.05）. Conclusions Urokinase induced by ultrasonic phonophoresis combined with routine thrombolytic therapy has significant effect in the treatment of acute lower limbs DVT.