新生儿败血症中性粒细胞CD64、CD11b的表达及临床意义

Expression of Neutrophil Cell CD64 and CD11b in Neonatal Septicemia and Its Clinical Significance

目的 探讨中性粒细胞CD64、CD11b对新生儿败血症早期诊断、判断病情及疗效的意义。方法 选择2011年3月1日至2012年5月30日收入我院新生儿普通病房的足月新生儿、出生体重2.5～4.0 kg、怀疑败血症患儿102例,于入院当天采血测定其中性粒细胞CD64、CD11b和血超敏CRP、ESR、WBC、I/T、血小板计数、血培养,其中败血症组42例,局部感染组60例,败血症组分别于入院第5、10天复查CD64、CD11b;非感染组选择同期住我院的26例非感染新生儿,入院当天抽血查CD64、CD11b。结果 败血症组CD64水平明显高于局部感染组和非感染组（均P〈0.01）,CD11b水平明显低于局部感染组和非感染组（均P〈0.01）;败血症组初期、中期和恢复期CD64水平逐渐下降（均P〈0.01）、CD11b水平逐渐上升（均P〈0.01）。结论 中性粒细胞CD64、CD11b可作为新生儿败血症早期诊断、判断疗效的指标之一。

Objective To explore the clinical significance of neutrophil cell CD64 and CD11b in the early diagnosis and evaluation of disease condition and efficacy of neonatal septicemia. Methods 102 neonates with suspected septicemia in our hospital from March 1, 2011 to May 30, 2012 were selected in this study. The blood samples of all cases were collected for blood culture and to detect the levels of CD64, CD11b, C reactive protein （CRP）, ESR, WBC, I/T, platelet. Among 102 cases, there were 42 cases of septicemia group, and 60 cases of local infection group. The septicemia group was given recheck of CD64, CD11b at the 5^th and 10^th of admission. 26 neonates without infection in our hospital at the same period were selected for control-study, and the levels of CD64 and CD11b were detected. Results The CD64 level of septicemia group was significantly higher than that of local infection group and non-infection group （both P 〈0.05）, and the CD11b level was significantly lower than that of local infection group and non-infection group （both P 〈0.05）. At the early phases, mid-phases and recovery phases, the CD64 level of septicemia group declined gradually （P〈0.01）, and CD11b level increased gradually （P 〈0.01）. Conclusions CD64 and CD11b are credible markers in early diagnosis and judgment of curative effect of neonatal sepsis.