溃疡性结肠炎肺功能损伤与内镜指数的关系

Relationship between Injured Lung Function and Endoscopic Index in Ulcerative Colitis Patients

目的:探寻溃疡性结肠炎(UC)不同肺功能损伤类型与肠镜内镜指数的相关性,客观评价肺肠表里关系,为临床诊治提供新依据。方法:选取2009年9月—2011年3月,我国多地三甲医院符合UC诊断且无呼吸系统疾病的患者,进行病史采集,同时对患者行肺功能、肠镜及病理组织学检查。结果:本研究共纳入171人,与正常组相比,异常组残气功能及弥散功能的内镜指数有统计学意义(P<0.05),其中残气功能组r=0.003,异常组通气功能、小气道功能无明显统计学意义。结论:溃疡性结肠炎存在不同类型肺功能损伤,其中残气功能、弥散功能异常与肠道损伤程度密切相关,且残气功能改变更为明显。

This study was aimed to find the relationship between lung function injured characteristic of ulcerativecolitis（UC） and endoscopic index. It will verify and enrich Chinese medicine theory to guide clinical diagnosis andtreatment. UC patients without respiratory system diseases were selected between September 2009 and March 2011 from several triple-A hospitals in China. Furthermore, disease history, lung function, colonoscopy and histopathologywere taken. The results showed that among 171 enrolled cases, there were statistical differences in endoscopic indexof residual-function and diffusion-function between the abnormal group and the normal group（P〈0.05）. The residual-function group wasr= 0.003. There were no statistical differences in ventilatory-function and small-airway-function in the abnormal group. It was concluded that there were different types of injured lung function in UC. Among them, the abnormalities of residual-function and diffusion-function had strong correlation with the intestinaldamage degree. The change on residual-function was more obvious.