microRNA-155评价肺癌生存结局效果的Meta分析

Meta analysis of the association between the expression of microRNA-155 and the outcome of patients with lung cancer

目的系统评价microRNA-155（miRNA-155）表达情况与肺癌患者生存结局的相关性。方法检索中国生物医学文献数据库、中国知识资源总库、维普资讯网、万方数据知识服务平台、SCIRUS搜索引擎、美国临床肿瘤学会和欧洲肿瘤内科学会会议论文库，收集2013年1月以前完成或发表的国内外miRNA-155表达情况与肺癌患者生存结局的相关性的病例对照研究，剔除不符合要求的文献，以漏斗图检验入选文献的偏倚，并考察入选文献的异质性质，将进行数据合并计算HR值。统计分析采用Stata12．0软件。结果共7篇文献符合条件纳入研究，入选文献无明显偏倚，剔除异质性来源的低分文献后，miRNA-155高表达可以预示非小细胞肺癌发生复发或转移等肿瘤相关恶性结局风险高（合并HR=1．48，95％c，1．07～2．06）。结论miRNA-155高表达与非小细胞肺癌不良结局具有相关性。

Objective To evaluate the association between the expression of microRNA-155 （miRNA-155） and the outcome of patients with lung cancer systemically. Methods 7 case-control studies about the expression of microRNA-155 that were based on our inclusion criterion and available in the literature were reviewed from CBM disc, CNKI, VIP, Wanfang data SCIRUS , ASCO and ESMO. Meta-analysis was carried out by Stata 12.0 software. Results Seven studies were included into the researches and there were no biased among the studies. After deleting the significant heterogeneity study, it showed significant association between the high expression of microRNA-155 and the outcome of patients with non-small cell lung cancer with the merged HR was 1.48 with 95% CI 1.07-2.06. Conclusion The current paper on Meta-analysis demonstrated a correlation between the high expression of miRNA-155 and the outcome of patients with non-small cell lung cancer.