期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

心房颤动治疗的心房选择性靶点 被引量：3

下载PDF
导出
摘要 理想的治疗心房颤动的抗心律失常药物,应该具有心房选择性,避免产生致室性心律失常作用。目前,认为具有心房选择性的药物靶点包括电压门控钾通道Kv1.5、电压门控钠通道Nav1.5、组成性激活内向整流性钾通道Kir3.1/3.4、缝隙连接蛋白等。文章就治疗心房颤动的心房选择性靶点做一综述。
作者 欧贤红 曾晓荣
机构地区 泸州医学院心血管医学研究所 泸州医学院心肌电生理学省部共建教育部重点实验室
出处 《中国循环杂志》 CSCD 北大核心 2014年第11期943-945,共3页 Chinese Circulation Journal
基金 国家自然科学基金(No.30870903) 四川省科技支撑计划项目(No.12ZC1759) 四川省卫生厅项目(130263)
关键词 心房颤动 心房选择性 抗心律失常药物 靶点
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献34

  • 1胡大一,杨进刚.心房颤动的现代观点 (1)我国心房颤动流行概况和危害[J].中国循环杂志,2004,19(5):323-324. 被引量：40
  • 2Wang Z, Fermini B, Nattel S. Sustained depolarization-induced outward current in human atrial myoeytes. Evidence for a novel delayed rectifier K* current similar to Kvl. 5 cloned channel currents. Circ Res, 1993, 73: 1061-1076.
  • 3Li GR, Feng J, Wang Z, et al. Adrenergie modulation of ultrarapid delayed rectifier K+ current in human atrial myocytes. Cire Res, 1996, 78: 903-915.
  • 4Schotten U, de Haan S, Verheule S, et al. Blockade of atrial-specificK+-currents increases atrial but not ventricular contractility by Na/Ca -exchange. Cardiovasc Res, 2007, enhancing reverse mode + 2+ 73: 37-47.
  • 5de Haan S, Greiser M, Harks E, et al, AVE0118, blocker of the transient outward current (It.) and ultrarapid delayed rectifier current (IK.), fully restores atrial contractility after eardioversion of atrial fibrillation in the goat. Circulation, 2006, 114: 1234-1242.
  • 6Ford J, Milnes J, Wettwer E, et a|. Human electrophysiological and pharmacological properties of XEN-DOI01: a novel atria|-selective Kv 1.5/IKur inhibitor. J Cardiovasc Pharmacol, 2013, 61 : 408-415.
  • 7Tamargo J, Caballero R, G6mez R, et al. IxJKfl. 5 channel blockers for the treatment of atrial fibrillation. Expert Opin lnvestig Drugs, 2009, 18: 399-416.
  • 8Finnin M. Vernakalant: A novel agent for the termination of atrial fibrillation. Am J Health Syst Pharm, 2010, 67:1157-1164.
  • 9Wettwer E, Christ T, Endig S, et al. The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation. Cardiovasc Res, 2013, 98:145-154.
  • 10Pavri BB, Greenberg HE, Kraft WK, el al. MK-0448, a specific kvl. 5 inhibitor: safety, pharmaeokinetics, and pharmacodynamie electrophysiology in experimental animal models and humans. Circulation: Arrhythmia and Electrophysiology, 2012, 5: 1193-1201.

二级参考文献39

  • 1周自强,胡大一,陈捷,张仁汉,李奎宝,赵秀丽.中国心房颤动现状的流行病学研究[J].中华内科杂志,2004,43(7):491-494. 被引量：1402
  • 2黄兵,陈雷,吴学仁,孙立忠,董超,刘振伟,李立环.慢性房颤患者右心房细胞电压依赖性钾电流变化的研究[J].中国病理生理杂志,2005,21(1):77-80. 被引量：9
  • 3张瑜,曾晓荣,杨艳,张标,刘智飞,李妙龄,周文,裴杰.持续性心房颤动患者I_(k1)电流密度及其基因表达变化的研究[J].中华心血管病杂志,2006,34(1):33-37. 被引量：9
  • 4Bosch RF,Zeng X,Grammer JB,et al.Ionic mechanisms of electrical remodeling in human atrial fibrillation.Cardiovasc Res,1999,44:121-131.
  • 5Xu Y,Tuteja D,Zhang Z,et al.Molecular identification and functional roles of a Ca2+ -activated K+ channel in human and mouse hearts.J Biol Chem,2003,278:49085-49094.
  • 6Tuteja D,Xu D,Timofeyev V,et al.Differential expression of small-conductance Ca2+-activated K+ channels SK1,SK2,and SK3 in mouse atrial and ventricular myocytes.Am J Physiol Heart Circ Physiol,2005,289:H2714-H2723.
  • 7Zhang Q,Timofeyev V,Lu L,et al.Functional roles ofa Ca2+-activated K+ channel in atrioventricular nodes.Circ Res,2008,102:465-471.
  • 8Ozgen N,Dun W,Sosunov EA,et al.Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites.Cardiovascular Research,2007,75:758-769.
  • 9Li N,Timofeyev V,Tuteja D,et al.Ablation ofa Ca2+ -activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.J Physiol,2009,587:1087-1100.
  • 10Nishida K,Michael G,Dobrev D,et al.Animal models for atrial fibrillation:clinical insights and scientific opportunities.Europace,2010,12:160-172.

共引文献74

同被引文献35

  • 1Jia Zhao,Rushil Randive,James A Stewart.Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart[J].World Journal of Diabetes,2014,5(6):860-867. 被引量：20
  • 2胡晓,黄曙荣,衣国华.偏瘫痉挛患者的康复护理[J].社区医学杂志,2006,4(05S):31-32. 被引量：6
  • 3Wilber D J, Pappone C, Neuzil P, et al. Comparison of anti- arrhyth-mic drug therapy and radiofrequency catheter abla- tion in patientswith paroxysmal atrial fibrillation: a random- ized controlled trial[ J]. JAMA ,2010,303 (4) :333 - 340.
  • 4Pappone C1, Vicedomini G, Augello G, et al. Radiofrequen- cycatheter ablation and antiarrhythmie drug therapy: a pro- spective, randomized ,g-year follow-up al : the APAF study [J]. Circ Ar-rhythm Electrophysiol, 2011,4 ( 6 ) : 808 - 814.
  • 5Fujii S, Shibazaki K, Kimura K, et al. A simple score for predicting paroxysmal atrial fibrillation in acute ischemic stroke[ J]. J NeurolSci ,2013,328 (1/2) :83 - 86.
  • 6马长生.心房颤动抗凝出血并发症的风险评估与处理[J].中国血栓之窗,房颤专刊,2012,2:23-26.
  • 7Azoulay L, Dell' Aniello S, Simon TA, et al. Initiation of- warfarin in patients with atrial fibrillation:early effects onis- chemic strokes [ J ]. Eur Heart J, 2014,35 ( 28 ) : 1881 - 1887.
  • 8Capucci A, Prisco D. The ROCKET AF study [ J ]. G Ital Cardiol(Rome) ,2012,13 ( 9 ) :553 - 556.
  • 9宋慧文.苦参素防治兔心房颤动心肌纤维化的实验研究[J].中国热带医学,2010,10(11):1395-1396. 被引量：3
  • 10无.老年人心房颤动诊治中国专家建议（2011）[J].中华老年医学杂志,2011,30(11):894-908. 被引量：58

引证文献3

二级引证文献10

中国循环杂志
2014年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部