1,3-丁二烯作业工人的DNA修复能力

DNA Repair Capacity of Workers Exposed to 1, 3-Butadiene

[目的]探讨DNA修复能力与1,3-丁二烯（BD）职业暴露致外周血淋巴细胞遗传学损伤的关联性。[方法]收集个人职业史、年龄、性别、吸烟和饮酒状况等信息,气相色谱法检测作业环境的BD浓度,利用染色体断裂试验评价60名职业BD暴露工人和60名非暴露工人的外周血淋巴细胞对诱变剂博莱霉素所致DNA损伤的修复能力。[结果]作业区空气中BD浓度为1.8（0.59~2.76）mg/m3。职业BD暴露组染色体断裂率[（1.06±0.41）%]高于对照组[（0.85±0.36）%,P〈0.01]。职业BD暴露人群中饮酒者的b/c值高于不饮酒者（P〈0.05）。[结论]DNA修复能力的下降可能是BD致癌过程中的重要生物学事件。

[Objective] To evaluate the short-term health effects of air pollutants on outpatient visits for respiratory diseases in Shanghai.[Methods] Daily data on outpatient visits to a Grade III Class A hospital for respiratory diseases, meteorological data, and air pollution data from January 1, 2010 to October 31, 2012 were collected.A time-series analysis by generalized additive model was conducted to examine the relationship between air pollutants and daily outpatient visits, controlling for time trends, day-of-week effect, holiday effect, and weather conditions.[Results] The daily outpatient visits for respiratory diseases ranged from 76 to 382 over the study period.In the single-pollutant model, SO2 concentration with lagged 4 days and NO2 and PM10 concentrations with lagged 6 days showed the most significant influence on outpatient visits.The excess relative risks of daily outpatient visits for a 10- μg/m3 increment in SO2, NO2, and PM10 were 0.69%（RR=1.006 9, 95%CI： 1.003 5-1.010 3）, 0.54%（RR=1.005 4, 95%CI： 1.002 8-1.007 9）, and 0.20%（RR=1.002 0, 95%CI： 1.001 1-1.002 8）, respectively.In the multiple-pollutant models, all pollutants effect estimates were lower compared with the results of the single-pollutant model when other pollutants were adjusted, but the positive correlations still existed between the pollutants and the daily outpatient visits for respiratory diseases.[Conclusion] The ambient air pollutant concentrations of SO2, NO2, and PM10 are positively associated with daily outpatient visits for respiratory diseases.