肿瘤转移抑制蛋白及上皮型钙黏蛋白在上尿路移行上皮癌中的表达

Expression of MTSS1 and E-cadherin in upper urinary tract transitional epithelial carcinoma

目的探讨肿瘤转移抑制蛋白（MTSS1）与上皮型钙黏蛋白（E-cadherin）在上尿路移行上皮癌中的表达情况及意义。方法收集病理科存档的60例上尿路移行上皮癌石蜡标本为观察组，同时取其中30例患者的膀胱正常组织作为对照组。采用免疫组织化学方法检测组织中MTSS1及E-cadherin的表达情况，并分析其表达与不同病理分期、分化程度及淋巴结转移间的关系。结果MTSS1在对照组的表达率为100．0％（30／30），在观察组表达率为45．0％（27／60），两组比较差异有统计学意义（P〈0．05）；E-cadherin在对照组表达率为96．7％（29／30），在观察组表达率为41．7％（25／60），两组比较差异有统计学意义（P〈0．05）；MTSS1与E—cadherin在不同病理分期、分化程度及淋巴结有无转移中表达率差异有统计学意义，分化程度好、TNM分期低、淋巴结无转移的患者中MTSS1与E-cadherin的表达率较高（P〈0．05）；MTSS1与E—cadherin在癌组织中的表达并无相关性（P〉0．05）。结论在上尿路移行上皮癌中联合检测MTSS1及E—cadherin的表达，对于判断肿瘤的恶性程度、淋巴结转移情况及患者的预后均有重要意义。

Objective To investigate the significance of MTSS1 and E-cadherin expression in upper urinary tract transitional epithelial carcinoma. Methods Paraffin specimens of 60 patients with upper urinary tract transitional epithelial carcinoma between January 2005 and January 2014 were analyzed. At the same time, 5 cm normal tissue adjacent to the cancerous tissue specimens in 30 patients were taken for comparison. Immunohistochemical method was used to detect the tissue MTSS1 and E-cadherin expression, and the relationships between their expression with different pathological stage, differentiated degree and lymph node metastasis were analyzed. Results MTSS1 expression rate in normal tissue （100.0% ,30/30） was significantly higher than that in cancerous tissue （45.0% ,27/60） and there was significant difference （P 〈 0.05 ）. E-cadherin expression rate in normal tissue （96.7%, 29/30） was significantly higher than that in cancerous tissue （41.7%, 25/60） and there was significant difference （P 〈 0.05）. The expression of MTSS1 and E-cadherin in different pathological stage, degree and with or without lymph node metastasis had significant difference （P 〈0.05）. In patients with well differentiated, low TNM stage and no lymph metastasis, MTSS 1 and E-cadherin expression rate was higher （P 〈 0.05）. There was no significant correlation between the expression of MTSS1 and E-cadherin in cancerous tissue （P 〉 0.05）. Conclusion In upper urinary tract transitional cell carcinoma detection of both MTSS1 and E-cadherin has important significance with regards to judging the malignant degree of the tumor, lymph node metastasis and prognosis in patients.