牙周基础治疗对2型糖尿病伴慢性牙周炎患者血清炎性细胞因子及糖化血红蛋白含量影响分析

Analysis of the level of inflammatory cytokines and glycosylated hemoglobin in patients with chronic periodontitis complicated with type 2 diabetes mellitus

目的探讨牙周基础治疗对2型糖尿病(T2DM)伴慢性牙周炎患者血清炎性细胞因子及糖化血红蛋白(HbAlc)含量的影响。方法选择2012年3月至2013年9月就诊于沈阳市口腔医院牙周科患者135例,其中T2DM伴慢性牙周炎患者63例(T2DM组),单纯慢性牙周炎患者72例(CP组);另从沈阳市口腔医院体检中心选择牙周健康正常人50名,作为正常对照组。于牙周基础治疗前及治疗后3个月,检查各组的牙周状况以及检测血清炎性细胞因子和HbAlc含量,并对检测结果进行比较分析。结果牙周基础治疗能改善慢性牙周炎患者的牙周健康状况,降低炎性细胞因子水平。牙周基础治疗前T2DM组和CP组的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)含量均高于正常对照组,差异有统计学意义(均P<0.05)。与牙周基础治疗前比较,T2DM组和CP组的CRP、TNF-α及IL-6含量在牙周基础治疗后3个月均明显下降,差异有统计学意义(均P<0.05)。牙周基础治疗前,T2DM组的HbAlc含量明显高于CP组和正常对照组;牙周基础治疗后3个月,T2DM组的HbAlc含量显著下降,且其治疗前后差异有统计学意义(P<0.05)。结论 T2DM伴慢性牙周炎患者进行牙周基础治疗,可改善患者的牙周状况和全身健康状况,从而减少糖尿病及其并发症的发生和发展。

Objective To investigate the relation ship between inflammatory cytokines and periodontal inflammation before and after periodontal treatment and discuss whether periodontal treatment could improve the level of glycosylated hemoglobin in patients with chronic periodontitis complicated with type 2 diabetes mellitus（T2DM）by reducing the level of inflammatory cytokines.Methods Totally 135 patients with chronic periodontitis were chosen from March 2012 to September 2013 in Stomatological Hospital of Shenyang,of whom there were 63 patients with T2DM（T2DM group）and 72 patients with only chronic periodontitis（CP group）. Fifty periodontal healthy individuals were chosen from Medical Center in Stomatological Hospital of Shenyang as the normal control group. Prior to periodontal treatment and for 3 months after treatment,determine periodontal status of each group and serum inflammatory cytokines and glycosylated hemoglobin（HbAlc） levels,and make comparative analysis of the test results.Results Periodontal treatment could improve the periodontal health in patients with periodontitis and reduce the level of inflammatory cytokines. Serum inflammatory cytokines CRP,TNF-α and IL-6 levels of T2 DM group and CP group after periodontal therapy for 3 months were significantly decreased,the difference being statistically significan（tP〈0.05）.Conclusion For T2 DM patients with chronic periodontitis,periodontal treatment can improve periodontal status and general health of the patient,thereby reduce the occurrence and development of diabetes and its complications.