核心蛋白聚糖在胆管癌中的表达及其临床意义

Expression of decorin in cholangiocarcinoma and clinical implication

目的 探讨胆管癌组织中核心蛋白聚糖表达的临床意义.方法 应用免疫组织化学方法检测44例胆管癌和40例正常胆管组织核心蛋白聚糖的表达,并分析核心蛋白聚糖的表达水平与胆管癌患者的性别、年龄、肿瘤细胞的分化程度和淋巴结转移的关系.结果 胆管癌组织核心蛋白聚糖表达明显下调,而在正常癌旁组织高水平表达.44例胆管癌患者胆管癌组织核心蛋白聚糖阳性18例（阳性率为40.91％）,而40例正常癌旁癌组织核心蛋白聚糖表达均呈阳性（阳性率为100.00％,P＜0.01）.高、中分化组肿瘤核心蛋白聚糖表达显著高于低分化组肿瘤（62.5％比15.0％,P＜0.01）.无淋巴结转移者中核心蛋白聚糖的表达（57.14％）明显高于已有区域淋巴结转移者（26.09％,P＜0.05）.核心蛋白聚糖的表达水平与胆管癌患者的性别、年龄、肿瘤的大小无明显相关.结论 核心蛋白聚糖在胆管癌组织中的表达具有一定肿瘤特异性.

Objective To investigate the clinical implication of the decorin expression in cholangiocarcinoma.Methods The decorin expression levels were detected by immunohistochemistry in 44 cases of cholangiocarcinoma and 40 cases of normal bile duct tissues.The relationship between the decorin expression level with sex,age,tumor cell differentiation and lymph node metastasis of patients with cholangiocarcinoma was analyzede.Results Decorin expression was down-regulated in human cholangiocarcinomas cancer tissues.Decorin protein was positive in tumor interstitial tissues and the staining was weaker in cholangiocarcinoma tissues than the adjacent noncancerous tissues.The positive expression rate of decorin in human cholangiocarcinomas cancer tissues and the adjacent normal tissues was 40.91% and 100.00%,respectively （P 〈 0.01）.The expression of decorin in middle-hight differentiation tumor group （57.14%） was significantly higher than in regional lymph node metastasis group （26.09%,P 〈 0.05）.The expression of decorin was not associated with sex,age and tumor cell differentiation of patients with cholangiocarcinoma.Conclusion The expression of decrorin appears to be tumor specificity to some extent in cholangiocarcinoma .