摘要
目的荟萃分析硝苯地平的群体药代动力学参数特征。方法获取研究文献中的群体药代动力学参数,经归一化处理,用SAS软件进行荟萃分析与评价。结果中国汉族人群与东亚人群相近,归为一个亚类,与其他两个亚类相比,存在明显差异。该亚类的药代动力学参数AUC、tmax、Cmax、t1/2分别为(292.53±8.01)ng·m L-1·h、(0.61±0.03)h、(140.01±11.38)ng·m L-1、(3.27±0.50)h。结论本研究验证了人种因素为影响硝苯地平药代动力学参数的一个重要因素,中国汉族人群所属的亚类人群服用硝苯地平应注意减少剂量。
Objective To cluster analysis the population pharmacokinet-ic characteristics of nifedipine.Methods The data of mean pharmacoki-netic parameters and other factors may affecting the pharmacokinetics of drug were collected, normalized, and compared by multivariate cluster a-nalysis procedure using SAS software.Results The pharmacokinetics of Chinese Han population was similar to that of east Asia populations clas-sified as a subgroup, with AUC was （292.53 ±8.01） ng·mL^-1· h, tmax was （0.61 ±0.03） h, Cmax was （140.01 ±11.38） ng·mL^-1 and t1/2 was （3.27 ±0.50） h, respectively.Conclusion The meta-analy-sis identified ethnic factor as a statistically significant factor of pharmaco-kinetics, subgroup of people located with Chinese Han population should reduce the dose of formulation.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2014年第11期1045-1047,1050,共4页
The Chinese Journal of Clinical Pharmacology
关键词
荟萃分析
药代动力学参数
硝苯地平
多因素聚类分析
人种因素
meta -analysis
pharmacokinetic parameter
nifedipine
multivariate cluster analysis
ethnic factor
