喹诺酮类抗菌药转运机制研究

Study on transport mechanism of quinolones

抗菌药物的疗效受病原体耐药、体内药物浓度及药物-药物相互作用等多种因素影响,而药物的转运方式及相应的载体蛋白对药物的疗效具有重要的作用。因此,本文对喹诺酮类抗菌药的转运机制及可能参与的载体蛋白进行收集与探讨。

Many factors contribute to the clinical treatment including pathogen resistance, in vivo concentrations of antimicrobials and drug-drug interactions.Transport mechanism and transporter proteins play an important role in the efficacy of drugs.In this paper, we will make a re-view on its transport mechanism and transporter proteins may be involve.