γδT细胞在类风湿性关节炎中的研究进展

Research advances in the role of γδT cells in the pathogenesis of rheumatoid arthritis

类风湿性关节炎（rheumatoid arthritis，RA）是一种常见的、系统性自身免疫性疾病，以慢性关节炎症、骨和软骨侵蚀及滑膜组织增生为特征，目前关于RA的发病机制尚未明确。γδT细胞是近年来人们新认识的一种表型和功能独特的T淋巴细胞亚群，外周血中γδT细胞仅占1％～10％，但在黏膜上皮组织中含量丰富，是固有免疫和适应性免疫的桥梁。研究显示γδT细胞可通过发挥抗原提呈功能、产生前炎性因子、B淋巴细胞辅助功能和免疫调节作用参与RA的发病机制。

Rheumatoid arthritis （RA） is a common systemic autoimmune disease charactenzea by cnromc inflammation of joints,bone and cartilage erosion, synovial hyperplasia, and the pathogenesis of RA is not clear. γδT cells are a new kind of phenotype and function T lymphocyte subsets, which mainly distribute in the mucosal and epithelial tissue and account for 1% - 10% of the total T cells in the peripheral blood, and bridge innate and adaptive immunity. γδT cells play an important role in the pathogenesis of RA by the functions of antigen-presenting capacity, secretion of proinflammatory cytokines,immunomodulatory effects, and auxiliary function for B cells.