氨溴索复合盐酸戊乙奎醚预防上呼吸道感染患儿急腹症手术后肺部并发症的效果

Efficacy of ambroxol combined with penehyclidine hydrochloride for prevention of pulmonary complications after surgery due to acute abdomen in pediatric patients with upper respiratory tract infection

目的 探讨氨溴索复合盐酸戊乙奎醚预防上呼吸道感染患儿急腹症手术后肺部并发症的效果.方法 合并呼吸道感染的急腹症患儿50例,ASA分级Ⅰ或Ⅱ级,年龄6个月～5岁,性别不限,体重不限,采用随机数字表法,将其分为2组（n=25）：试验组（A组）和对照组（B组）.入手术室后即刻A组静脉注射氨溴索1 mg/kg、盐酸戊乙奎醚0.02 mg/kg;B组静脉注射阿托品0.02 mg/kg.记录气管拔管时间、拔除气管导管后喉痉挛、支气管痉挛以及低氧血症的发生情况,于术后72 h内随访,记录术后肺部并发症的发生情况.结果 与B组比较,A组低氧血症和术后肺部并发症发生率降低,气管拔管时间缩短（P＜0.05）.结论 氨溴索复合盐酸戊乙奎醚可预防上呼吸道感染患儿急腹症手术后肺部并发症,有利于预后.

Objective To investigate the efficacy of ambroxol combined with penehyclidine hydrochloride for prevention of pulmonary complications after surgery due to acute abdomen in pediatric patients with upper respiratory tract infection. Methods Fifty pediatric patients with acute abdomen complicated with respiratory infection, of ASA physical status Ⅰ or Ⅱ , aged 6 months-5 yr, were randomly divided into test group （group A） and control group （group B） , with 25 cases in each group. Immediately after admission to the operating room, ambroxol 1 mg/kg and penehyclidine hydrochIoride 0.02 mg/kg were injected intravenously in group A, and atropine 0.02 mg/kg was given in group B. Extubation time and development of laryngospasm, bronchospasm and hypoxemia were recorded. The patients were followed up for 72 h after surgery and the development of postoperative puhnonary complications was recorded. Results Compared with group B, the incidence of hypoxemia and pulmonary complications was significantly decreased, and extubation time was shortened in group A. Conclusion Ambroxol combined with penehyclidine hydrochloride can prevent pulmonary complications after surgery due to acute abdomen and is helpful for prognosis in pediatric patients with upper respiratory tract infection.