全麻诱导时不同静脉给药顺序对芬太尼诱发咳嗽的影响

Effects of different sequences of intravenous administration on fentanyl-induced cough during induction of general anesthesia

目的 评价全麻诱导时不同静脉给药顺序对芬太尼诱发咳嗽的影响.方法 全麻下择期手术患者100例,性别不限,年龄18 ～ 70岁,体重42 ～ 88 kg,ASA分级Ⅰ或Ⅱ级,采用随机数字表法,将其分为2组（n=50）：芬太尼-异丙酚组（FP组）静脉注射芬太尼3μg/kg,3 s注射完毕,随后静脉注射异丙酚1.5 mg/kg;异丙酚-芬太尼组（PF组）先静脉注射异丙酚1.5 mg/kg,随后静脉注射芬太尼3μg/kg,3 s注射完毕.记录注射芬太尼后1 min内咳嗽的发生情况、程度和出现时间.结果 与FP组比较,PF组咳嗽发生率降低（P＜0.05）,咳嗽出现时间和程度差异无统计学意义（P＞0.05）.结论 与芬太尼-异丙酚给药比较,异丙酚-芬太尼给药可减少全麻诱导时芬太尼诱发的咳嗽.

Objective To evaluate the effects of different sequences of intravenous administration on fentanyl-induced cough during induction of general anesthesia.Methods One hundred patients of both sexes,aged 18-70 yr,weighing 42-88 kg,of ASA physical status Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were equally randomized to 2 groups using a random number table：fentanyl-propofol group （group FP） and propofol-fentanyl group （group PF）.In FP group,fentanyl 3 μg/kg was injected intravenously over 3 s,and then propofol 1.5 mg/kg was injected intravenously.In PF group,propofol 1.5 mg/kg was injected intravenously,and then fentanyl 3μg/kg was injected intravenously over 3 s.The development,intensity and onset time of cough were recorded within 1 min after fentanyl injection.Results Compared with FP group,the incidence of cough was significantly decreased,and no significant change was found in the intensity and onset time of cough in PF group.Conclusion Administration in the propofol-fentanyl sequence can reduce the development of fentanyl-induced cough as compared with that in the fentanyl-propofol sequence during induction of general anesthesia.