不同药物应用于子宫内膜异位症腹腔镜术后的疗效及安全性

目的：对比分析子宫内膜异位症腹腔镜术后服用不同药物的临床疗效及安全性。方法选择江西九江市九江县妇幼保健院2012年3月～2013年10月行腹腔镜手术治疗子宫内膜异位症患者70例，随机均分为米非司酮组（给予米非司酮辅助治疗）与孕三烯酮组（给予孕三烯酮辅助治疗）（n=35），比较2组的缓解率、复发率、妊娠率和不良反应。结果米非司酮组完全缓解率为82.9%，孕三烯酮组完全缓解率为85.7%，2组术后复发率均为2.8%，妊娠率均为66.7%，差异均无统计学意义。米非司酮组1例患者出现用药不良反应，孕三烯酮组9例出现不良反应，2组比较差异有统计学意义（P＜0.05）。结论子宫内膜异位症腹腔镜术后应用米非司酮辅助治疗疗效明显，不良反应少，安全性高，值得临床推广应用。

Objective Analysis of clinical efficacy and safety of different drugs in patients taking in endometriosis after laparoscopic uterine. Methods Selection of laparoscopic operation in treatment of endometriosis patients with a total of 70 cases in the hospital. These cases were randomly divided into Mifepristone group （The use of mifepristone for adjuvant treatment） and pregnant three ketene group （The use of pregnant three ketene adjuvant therapy） with 35 patients in each group, Compared with two groups of remission rate, relapse rate, pregnancy rate and adverse reaction. Results The mifepristone group complete remission rate was 82.9%, pregnant three ketene group complete remission rate was 85.7%, two groups of postoperative recurrence rate was 2.8%, pregnancy rate was 66.7%, the difference was not statistically significant. 1 cases of adverse reactions in patients with drug mifepristone group, 9 cases of adverse reactions pregnant three ketene group, there was significant difference between two groups （P〈0.05）. Conclusion Laparoscopic surgery in ectopic endometrium of uterus after mifepristone treatment obviously curative effect, with fewer side effects, higher safety. It is worthy of clinical application.