益生菌治疗溃疡性结肠炎的选择临床分析

Clinical analysis of selecting probiotics in treatment of ulcerative colitis

目的对溃疡性结肠炎患者临床上口服益生菌双岐杆菌胶囊治疗效果的观察分析。方法将108例临床诊断为溃疡性结肠炎的患者随机分成两组。治疗组口服双岐三联活菌片加以合并柳氮磺胺吡啶,并注意改善患者生活习惯,对照组口服甲硝唑片联合柳氮磺胺吡啶,与治疗组在同样治疗环境下,持续服药4周。两组在4周后均通过复查后肠镜,比较治疗效果。结果治疗组总有效率92.59%,对照组总有效率为72.22%,治疗组和对照组完全缓解率分别为51.85%、31.48%,6个月后复发率分别为3.70%、16.67%,通过SPSS 17.0分析,均有统计学意义(P<0.05)。结论患者在口服给予双岐杆菌三联活菌联合柳氮磺胺吡啶后,持续监测得知,联合用药提高了药物治疗溃疡性结肠炎效果,建议其能广泛使用于临床中。

Objective To observe and analyze the Oral Bifidobacterium Capsules and treatment effect of ulcerative colitis in clinical .Methods Selected 108 cases that were diagnosis as ulcerative colitis , and divided them into two groups randomly .The therapy group oral Bifidobacterium triple viable piece and merged with sulfasalazine, during treatment period , we must pay attention to improving patients＇living habits.And in the control group was treated with metronidazole tablets combined sulfasalazine , and keep the patients in the same therapeutic environment as the therapy group , continuous medication for 4 weeks.After four weeks, we review the colonoscopy , comparing the treatment effect between the two groups .Results The therapy group＇s total effective rate was 92.59%, in the comparing with control group;the total effective rate was 72.22%.The treatment group and the control group＇s complete remission rate were 51.85% and 31.48% respectively.And after six months, the relapse rates were 3.70% and 16.67 % respectively.By analyzing the data with SPSS17.0, they were all statistically significant （ P 〈0.05 ）.Conclusions After oral administration triple viable Bifidobacterium combined sulfasalazine , and through continuous monitoring , we find that combination therapy increased the effectiveness of drug in the treatment of ulcerative colitis , suggest that these combination therapies could be widely used in clinical practice .