泌尿生殖道感染支原体耐药性的变迁

Changes of mycoplasma drug resistant in urogenital tract infection

目的：研究泌尿生殖道感染支原体耐药性的变迁。方法：对2004年到2012年就诊的泌尿生殖道感染患者进行支原体培养及药敏检测，分三个时间段对药敏变化进行分析。结果：在三个时间段里，强力霉素、四环素和克拉霉素的耐药率有上升的趋势；交沙霉素、阿奇霉素和红霉素耐药率有下降的趋势；原始霉素、氧氟沙星和环丙沙星耐药率无变化。结论：随着时间的变化，支原体的耐药性也会发生改变，治疗支原体感染应尽量根据药敏结果选用抗生素，经验用药应选原始霉素、交沙霉素和强力霉素。

Objective：To investigate urogenital tract mycoplasma inflection and drug-resistance evolution from 2004 to 2012.Methods：The result of mycoplasma culture and drug sensitivity test were explored from 2004 to 2012 . This study divided the research objectives into three groups according to time difference and analysed the difference of drug resistance between these three groups.Results：As time passed by, the drug resistance rates to doxycycline , tetracycline , clarithromycin increased, the drug resistance rates to josamycin, azithromycin and erythromycin decreased , but the drug resistance rates to pristinomycin, ofloxacin and ciprofloxacin did not change significantly.Conclusions：The drug sensitivity evolves with time. Treatment for mycoplasma should be based on the results of drug sensitivity tests. So the antibacterial choice without drug-resistance test should be Pristinomycin, josamycin and doxycycline.