乌鲁木齐市维吾尔族、汉族低出生体重儿甲状腺激素水平及代谢酶相关性研究

Study on the correlation between thyroid hormone levels and metabolic enzymes among low birth weight infants of Uighur nationality and Han nationality in Urumqi

目的：探讨乌鲁木齐市维吾尔族、汉族低出生体重儿甲状腺激素（thyroid hormone,TH）水平及其与代谢酶活性的相关性。方法：收集2013年3~12月在乌鲁木齐市儿童医院分院、新疆维吾尔自治区妇幼保健院或新疆维吾尔自治区人民医院出生的正常出生体重儿和低出生体重儿脐带血,检测TH水平、细胞色素P450（CYP450）、尿苷二磷酸葡萄糖醛酸转移酶（UGT）及硫酸转移酶（SULT）酶活性。结果：与正常出生体重儿相比,维吾尔族、汉族低出生体重儿三碘甲腺原氨酸（T3）及四碘甲腺原氨酸（T4）水平均明显降低（P〈0.05）,TSH水平明显升高（P〈0.05）;维吾尔族、汉族低出生体重儿CYP450、UGT及SULT酶活性均高于正常出生体重儿（P〈0.05）。结论：TH相关代谢酶活性增加与维吾尔族、汉族低出生体重儿TH水平降低有关,但其机制需要进一步探讨。

Objective： To explore the correlation between thyroid hormone （TH） levels and metabolic enzymes activities among low birth weight infants of Uighur nationality and HaM nationality in Urumqi. Methods： Umbilical cord blood specimens of normal birth weight infants and low birth weight infants born in Urumqi from March to December in 2013 were collected, TH levels, CYP450, UGT and SULT activities were detected. Results： Compared with normal birth weight infants, the levels of triiodothyronine and tetraiodothyronine in low birth weight infants of Uighnr nationality and HaM nationality decreased significantly （ P 〈 0. 05 ）, the levels of TSH increased significantly （P 〈 0.05） ; CYP450, UGT and SULT activities in low birth weight infants of Uighur nationality and HaM nationality were statistically significantly higher than those in normal birth weight infants （ P 〈 0.05） . Conclusion： The increases of TH - associated metabolic enzymes activities are correlated with decreases of TH levels in low birth weight infants of Uighur nationality and HaM nationality, but the mechanism should be further studied.