乳腺肿瘤2374例临床病理分析

Clinicopathological analysis on breast tumor in 2374 cases

目的统计北京市大兴区人民医院近10年手术切除的乳腺肿瘤2 374例,分析其组织学特点,为地区妇女保健工作的开展提供科学依据。方法回顾整理2003-2012年手术切除乳腺肿瘤的病理资料,严格按照世界卫生组织乳腺肿瘤标准（2012）进行病理诊断及分类。结果 2 374例乳腺肿瘤患者中良性肿瘤1 900例（80.0%）,恶性肿瘤474例（20.0%）,良、恶性之比4.01∶1,好发部位均以左侧多见,良性肿瘤可同时发生在双侧乳腺,而恶性肿瘤同时发生在双乳的情况在本组研究中未见。乳腺良性肿瘤中以乳腺纤维腺瘤（70.5%）多见,乳腺良性肿瘤平均发病年龄约为31.6岁;恶性肿瘤中以浸润性癌（非特殊型）为多见,占81.3%,乳腺恶性肿瘤平均发病年龄约为52.3岁。年轻妇女乳腺癌（35岁或35岁以下）占5.91%。结论研究结果显示乳腺肿瘤以良性肿瘤为主,好发于左侧乳腺,乳腺良性肿瘤以纤维腺瘤最为常见,恶性肿瘤以浸润性癌（非特殊型）最常见。乳腺良性肿瘤发病年龄高峰在21-30岁,乳腺恶性发病年龄高峰在41-50岁。年轻妇女（35岁及以下）乳腺恶性肿瘤患病率在国内处于较低水平。

Objective To summarize the pathological characteristics of specimens of breast tumors in 2374 cases in this hospital during recent 10 years,and to analyze the characteristic histological features in order to provide a scientific basis for implementation of women＇s health care in this region. Methods The data of surgical removal specimens of breast tumor during 2003 to 2012 in this hospital were retrospectively reviewed and analyzed,according to the criteria of WHO for breast tumor classification（ 2012） for pathological diagnosis and classification. Results Among these 2 374 cases of surgical removal specimens of breast tumors,there were 1 900 cases of benign tumors（ 80. 0%）,474 cases of malignant tumors（ 20. 0%）. The ratio of benign to malignant tumors was 4. 01 ∶ 1,The most common position was in left side of breast,the benign tumors usually occurred in both sides,and malignant tumors might occasionally occurred in both sides in this study. Among benign tumors,fibroadenoma was the most common benign tumor（ 70. 5%）,the average age for benign tumors was 31. 6 years old. Among malignant tumors,invasive ductal carcinoma（ not specified） was the most common（ 81. 3%）,and the average age for malignant tumors was 52. 3 years old. The young women（ 35 years old or below） with breast cancer accounted for 5. 91%. Conclusion This study demonstrates among breast tumors,benign tumors are most common,they usually occurred at left breast. Among benign tumors,fibroadenoma is the most common one. Invasive ductal carcinoma（ not specified） is the most common in malignant tumors. The peak age of onset for benign breast tumors is at the age of 21 - 30 and the peak age for malignant tumors is at age of 41 - 50. The morbidity of young women（ 35 years old or below） with malignant breast tumors is at lower level in this country.