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miRNA体内转染的研究进展 被引量：4

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摘要 微小RNA（MicroRNAs,miRNAs）是一种内源性非编码RNA,主要参与基因转录后水平的调控。虽然miRNA的生物学功能刚刚被人们熟知,它在疾病的发病和进展中所显现的治疗潜力已引起人们极大的兴趣。越来越多的证据表明,以miRNA为基础的基因治疗,不管是增强或抑制miRNA的表达和活性,都有很大的应用前景。但是靶向特定器官和组织特异性差的缺点,使得其应用于临床还存在限制。
作者 马东青 崔红
机构地区 首都医科大学附属北京友谊医院儿科
出处 《临床和实验医学杂志》 2014年第21期1825-1829,共5页 Journal of Clinical and Experimental Medicine
关键词 微小RNA 体内转染 治疗 非病毒载体
分类号 R440 [医药卫生—诊断学]
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参考文献38

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同被引文献48

  • 1LAFARP K J, DEMIRJIAN AN, PAWLIK TM. Epidemiology of hepatocellular carcinoma[ J ]. Surg Oncol Clin N Am, 2015, 24(1). 1 -17.
  • 2SIEGEL RL, MILLER KD, JEMAL A. Cancer statistics, 2015[J]. CA Cancer J Clin, 2015, 65(1 ). 5 -29.
  • 3POZZAN C, CARDIN R, PICrOCCHI M, et ai. Diagnostic and prognostic role of SCCA- IgM serum levels in hepatocellular carcinoma (HCC)EJ]. J Gastroenterol Hepatoi, 2014, 29 (8) : 1637 -1644.
  • 4FOMER A, DIAZ -GONZALEZ A, LICCIONI A, et al. Prog- nosis prediction and staging[J]. Best Pract Res Clin Gastro- enterol, 2014, 28(5) : 855 -865.
  • 5HA M, KIM VN. Regulation of microRNA biogenesis [ J]. Nat Rev Mol Cell Biol, 2014, 15(8) : 509 -524.
  • 6POGRIBNY IP, RUSYN I. Role of epigenetic aberrations in the development and progression of human hepatocellular carcino- ma[J]. Cancer Lett, 2014, 342(2) : 223 -230.
  • 7YANG N, EKANEM NR, SAKYI CA, et al. Hepatocellular carci- noma and microRNA: new perspectives on therapeutics and di- agnostics[J]. Adv Drug Deliv Rev, 2015, 81C: 62 -74.
  • 8ZHU Z, ZHANG X, WANG G, et al. Role of microRNAs in hepatocellular carcinoma[J]. Hepat Mon, 2014, 14 (8): e18672.
  • 9CALLEGARI E, GRAMANTIERI L, DOMENICALI M, et al. Mi- croRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches[J]. Cell Death Differ, 2015, 22( 1 ) : 46 -57.
  • 10BERTINO G, NERI S, BRUNO CM, et al. Diagnostic and prog- nostic value of alpha -fetoprotein, des - gamma - carboxy pro- thrombin and squamous cell carcinoma antigen immunoglobulin M complexes in hepatocellular carcinoma [ J ]. Minerva Med, 2011, 102(5) : 363 -371.

引证文献4

二级引证文献11

临床和实验医学杂志
2014年 第21期

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