无症状反流性食管炎患者静息期功能性磁共振成像脑区活动特征分析

Study on functional MRI for visceral hypersensitivity in patients with asymptomatic reflux esophagitis

目的探讨无症状反流性食管炎患者静息期功能性磁共振成像脑区活动特征。方法选择食管炎患者共28例,包括无症状(研究组)和有症状(对照组)患者各14例,在静息期进行功能性磁共振成像(f MRI)扫描,观察并比较两组脑区活动特征。结果两组在静息期f ALFF值均存在显著高于全脑平均值的脑区。当zf ALFF的差异阈值=2.1103时,可见研究组患者在右侧中央沟盖、右侧颞上回、右侧颞横回、右侧中央后回较对照组患者f ALFFz值明显减低(P<0.01),峰值点Talairach空间坐标为(45,-4,11),激活体素个数为121,峰激活强度为2.1799。结论无症状反流性食管炎患者静息期功能性磁共振成像脑区活动出现特殊变化,内脏感觉敏感性变化在无症状反流性食管炎患者发病中起着重要作用。

Objective To explore the characteristics of cerebral activity at resting period in patients with asymptomatic reflux esophagitis.Methods A total of 28 patients with esophagitis were collected,including asymptomatic and symptomatic patients（ 14 cases for each）. Functional magnetic resonance imaging（ f MRI） had been scanned and compared at the resting period. Results The value of f ALFF was significantly higher in these two groups than the average value of the whole brain in resting period. When the differntial threshold value of zf ALFF was 2. 1103,P 0. 01 in the study group,f ALFF value at the right side of the central sulcus cover,right temporal gyrus,right inferior temporal transverse gyrus and right posterior central gyrus were significantly lower than those of control group. Peak point at Talairach space coordinates was（ 45,- 4,11）,with the number- activated body of 121,the peak activated intensity of 2. 1799. Conclusion Specific changes have been occurred in resting functional magnetic resonance imaging of brain activity in patients with asymptomatic reflux esophagitis. The change in visceral sensory sensitivity plays an important role in pathogenesis of asymptomatic reflux esophagitis.