卵巢浆液性乳头状腺癌组织中上皮-间充质转变调控基因Slug的表达及其临床预后意义

The expression of Slug in ovarian papillary serous adenocarcinoma and its clinical prognosis significance

目的:研究上皮-间充质转变调控基因Slug在卵巢浆液性乳头状腺癌组织中的表达及其临床预后意义。方法:采用免疫组织化学(EnVisionTM)法分别检测80例卵巢浆液性乳头状腺癌组织及其癌旁组织中Slug的表达,并运用Kaplan-Meier法分析Slug的表达对患者预后的影响。结果:上皮-间充质转变调控基因Slug在卵巢浆液性乳头状腺癌组织及癌旁组织中的阳性表达率分别为52.50%、13.75%,两者之间差异有统计学意义(χ2=27.11,P<0.01);上皮-间充质转变调控基因Slug的表达与TNM分期、淋巴结转移、远处脏器转移、雌激素阳性表达有关(P<0.05),但与患者年龄、肿瘤直径、组织学分化无关(P>0.05);卵巢浆液性乳头状腺癌组织上皮-间充质转变调控基因Slug表达阴性的患者生存率明显高于阳性患者(χ2=4.09,P<0.05)。结论:卵巢浆液性乳头状腺癌组织中上皮-间充质转变调控基因Slug过表达可能有利于癌组织的转移,也预示患者预后不良。

Objective： To study the expression of epithelial-mesenchymal transition controlling gene Slug in ovarian papillary serous adenocarcinoma and its clinical prognosis significance, Methods： Slug was respectively detected by immunohistochemisty（ EnVisionTM） in ovarian papillary serous adenocarcinoma with 80 cases and their cancer side tissue, and the expression of Slug was analyzed by Kaplan-Meier to assess their influence on patients. Results： The positive expression rate of Slug in ovarian papillary serous adenocarcinoma and cancer side tissue was respectively 52.50% and 13.75%, which was statistically different between them （X^2 = 27. 11, P 〈 0.01 ）. The positive expression of Slug was related to TNM staging, lymph node metastasis, distant place organ metastasis and ER positive expression（P 〈 0.05 ）, but not to age, tumor size and histological differentiation （ P 〉 0.05 ）. The survival rate of negative Slug in ovarian papillary serous adenocarcinoma was obviously more than positive Slug （X^2 = 4.09,P 〈 0.05 ）. Conclusion： The overexpression of Slug in ovarian papillary serous adenocarcinoma may be useful to cancer metastasis and imply the poor prognosis.