215例药品不良反应报告分析

Adverse Drug Reactions: Analysis of 215 Cases

目的:了解广州开发区医院药品不良反应(ADR)发生情况及引发ADR的相关因素,促进临床合理用药。方法:对该院2009—2013年收集的215例ADR报告分别从报告类型、患者年龄、给药途径、涉及药物种类以及临床具体表现等方面进行统计、分析。结果:215例ADR中,严重的ADR为15例(占7.0%);青年患者较多,为119例(占55.4%);静脉滴注引发的ADR为186例(占86.52%);抗菌药物引发的ADR为118例(占54.88%);ADR的临床表现以皮肤、黏膜及附件损伤为最常见,为120例次(占总例次数的42.86%)。结论:临床应提高ADR监测报告质量,加强抗感染药的合理使用,减少ADR的发生,保障公众用药安全。

OBJECTIVE：To investigate the occurrences of adverse drug reactions （ADRs） and the associated factors of the ADRs in Guangzhou Development District Hospital so to promote clinical rational use of drugs. METHODS： 215 ADR case reports collected in Guangzhou Development District Hospital during the period 2009-2013 were analyzed statistically in respect of types of ADR report, patients＇ age distribution, route of administration, drug varieties and the specific clinical manifestation etc. RESULTS ： Of the total 215 ADR cases, 15 （ 7.0% ） were regarded as serious ones; 119 （55.4%） were young adults; 186 cases （86.52%） were induced by ivgtt; 118 （54. 88% ） were induced by antibiotics; 120 cases （42. 86% ） manifested as damage of skin and appendents. CONCLUSIONS ： It is important to improve the quality of ADR monitoring and reporting and intensify and rational use of anti-infective drugs in order to reduce the incidence of ADR and ensure public medication safety.