摘要
目的:为临床药师尽快建立慢性乙型病毒性肝炎(Chronic Viral Hepatitis B,CH-B)药学服务模式提供参考。方法:收集药师参与跟踪的在厦门市中医院住院的67例CH-B患者资料、56例住院并进行抗病毒治疗的CH-B患者资料、34例住院并注射干扰素治疗的CH-B患者资料,并进行综合分析,探索药学服务模式。结果:67例患者中,低血糖症发生率为11.94%;56例患者中,口服核苷类药患者自行停药发生率为27.78%,注射干扰素患者中无自行停药者;34例患者中,干扰素不良反应发生率高,主要为流感样症状、血液系统不良反应。临床药师由此建立药学服务模式,进行针对性的药学监护。结论:临床药师应从不同角度参与CH-B患者的药学服务,如预防低血糖反应的药学监护、乙型肝炎病毒学突破的药学监护、抗乙型肝炎病毒药物主要不良反应的药学监护、联合应用抗病毒药的药学监护、降低用药成本的药学监护等,以提高患者用药的安全性。
OBJECTIVE：To provide reference for clinical pharmacists to establish pharmaceutical care mode as soon as possible for patients with chronic viral hepatitis B （CH-B）. METHODS ： The clinical data of 67 CH-B cases, 56 CH-B cases receiving antiviral therapy and 34 CH-B cases receiving interferon injection during hospitalization in Xiamen Hospital of Traditional Chinese Medicine followed-up by pharmacists were given meta-analysis to explore the pharmaceutical care mode. RESULTS： Of the 67 cases, hypoglycemia occurred in 11.94% ; of the 56 cases, self- withdrawal of oral nucleoside drugs occurred in 27.78%, while the self-discontinuation of interferon injection in none; of the 34 cases, high incidence of adverse reactions induced by interferon was noted, which manifested chiefly as influenza-like symptoms and adverse reactions of hematological system. Thereby, clinical pharmacist established pharmaceutical care mode and carried out corresponding pharmaceutical care for the patients. CONCLUSIONS： Clinical pharmacists should carry out pharmaceutical care from different aspects, such as the pharmaceutical care on prevention of hypoglycaemic reaction, on combined use of antiviral drugs and on the reduction of medication costs so as to improve patients＇ medication safety.
出处
《中国医院用药评价与分析》
2014年第10期950-952,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
