疏风解毒胶囊联合抗生素治疗糖尿病合并肺部感染临床观察

Combination of “Shufeng Jiedu Capsule”and antibiotics for the treatment of diabetes combined with pulmonary infection

目的观察疏风解毒胶囊治疗糖尿病合并肺部感染的临床疗效。方法将223例糖尿病合并肺部感染患者随机分为对照组(120例)和治疗组(103例)。对照组给予常规抗生素治疗,治疗组给予抗生素联合疏风解毒胶囊治疗。两组疗程均为14天,观察生存率、体温、血糖(BG)、血酮、血清丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、肌酐(Cr)、C反应蛋白(CRP)、乳酸、降钙素原(PCT)、氧合指数的变化情况。结果 1治疗组生存率为96.1%,对照组为97.5%,两组生存率无显著性差异(P>0.05)。2治疗组体温控制、血糖异常升高、血酮阳性率、ALT、AST、Cr、CRP、乳酸、PCT改善较对照组明显(P<0.05,P<0.01)。3治疗组氧合指数较对照组高(P<0.05)。结论疏风解毒胶囊有助于控制糖尿病合并肺部感染的炎症反应,提高氧和指数。

Objective To observe the clinical efficacy of ＂Shufeng Jiedu Capsule＂ in treating diabetes combined with pulmonary infection. Methods Two hundred and twenty-three cases were randomized into treatment group （n = 103 ） and control group （n = 120）. Control group was treated by conventional antibiotic therapy, and treatment group was treated by ＂Shufeng Jiedu Capsule＂ and antibiotics, with the course of 14 days. The survival rate, temperature, and levels of blood glucose, blood ketone, alanine aminotransferase （ALT）, aspartate amiuotransferase （AST）, creatinine （Cr）, C reactive protein （CRP）, lactate, procalcitouin （PCT）, and oxygenation index were observed. Results （1） The survival rate was 96.1% in the treatment group and 97.5% in the control group, without significant difference between the two groups （ P 〉 0.05 ）. （2） Compared with control group, the body temperature, blood glucose, blood ketone, ALT, AST, Cr, CRP, lactate and PCT were decreased significantly in the treatment group （P 〈 0.05, P 〈 0.01 ）. （3）The oxygenation index in the treatment group was higher than that of the control group （ P 〈 0.05 ）. Conclusion ＂Shufeng Jiedu Capsule＂ can control the inflammatory response and improve the oxygen index in patients with diabetes complicated with pulmonary infection.