临床分离念珠菌的特征及耐药性研究

STUDY ON THE CHARACTERISTIC AND DRUG RESISTANCE OF CLINICAL ISOLATES OF CANDIDA ALBICANS

目的研究临床分离念珠菌的特征及其耐药性,为合理用药提供参考依据。方法采用真菌分离鉴定技术和药敏试验方法,对某医院住院患者临床送检标本进行念珠菌种类调查和耐药性分析。结果调查期间从该医院临床送检病原学标本中,共检出念珠菌497株,分离菌株数居前三位的科室是呼吸科、重症监护病房和神经内科。有54.33%的菌株分离自呼吸道标本,另有16.70%的标本为泌尿生殖道标本。临床分离的念珠菌主要是白色念珠菌,占62.78%,其次是光滑念珠菌。临床分离的念珠菌对5-氟胞嘧啶和两性霉素B敏感率较高,但耐药率呈现逐年增加趋势。结论临床分离的念珠菌多数为白色念珠菌,主要为呼吸道感染,对抗念珠菌药敏感率均在60%以上,但耐药性有增加趋势。

Objective To study the characteristics and drug resistance of clinical isolates of Candida albicans, and to provide reference for rational drug use. Methods Fungal isolation and identification and drug sensitive test methods were used to analyze fungal species and drug resistance of clinical samples in a hospital. Results During the period of investigation, there were 497 strains of fungi isolated from the hospital clinical laboratory pathogenic specimens. The number of top three in department were department of respiration, ICU and neural department of internal medicine. 54.33% strains were isolated from respiratory tract specimens, and 16.70% were isolated from Genitourinary tract specimens. Clinical isolated fungi was mainly Candida albicans, accounted for 62.78%, followed by Candida glabrata. Clinical isolated fungi was sensitive to 5 - fluorocytosine and amphoteriein B, but the resistance rate was increasing year by year. Conclusion Most clinical isolated fungi are Candida albicans, mainly for respiratory tract infection, and the antifungal drug sensitive rate is above 60%. But the resistance has increasing tendency.