非霍奇金淋巴瘤组织中Survivin基因表达水平及临床意义

Non-hodgkin's lymphoma in Survivin gene expression levels in the organization and its clinical significance

目的:探讨Survivin基因在非霍奇金淋巴瘤组织中的表达及临床意义。方法:采用免疫组织化学方法检测非霍奇金淋巴瘤组织标本中的Survivin表达;采用Kaplan-Meier生存曲线分析方式进行非霍奇金淋巴瘤患者Survival统计分析。结果:对照组人群中Survivin基因阳性表达反应率0.75%,显著低于惰性(15.73%)和侵袭性(54.01%)淋巴瘤患者Survivin阳性反应率;惰性淋巴瘤患者的Survivin阳性反应率也显著低于侵袭性淋巴瘤患者;Survivin在非霍奇金淋巴瘤组织的表达量与年龄、免疫表型、临床分期及发生部位等临床病理指标均无关,组内比较没有统计学差异;乳酸脱氢酶(LDH)≤250U/L的非霍奇金淋巴瘤患者组织Survivin阳性反应率(23.08%)显著低于LDH>250U/L患者(48.65%);Survivin阳性表达>25%患者生存率显著低于Survivin阳性表达<25%的患者。结论:Survivin可能会成为肿瘤早期诊断和预后预测的新肿瘤标志物。

objective：To evaluate the role of Survivin gene in the expression and clinical significance of non‐hodgkin＇s lymphoma tissue .Methods ：Using immunohistochemical methods expression of survivin in non‐hodgkin＇s lymphoma tissue samples ;Using Kaplan Meier survival curve analysis method for non‐hodgkin＇s lymphoma patients survival statistics analysis .Results ：In the control group in the crowd ,survivin gene expression positive re‐sponse rate was 0 .75% lower than inert （15 .73% ） and invasive survivin positive response rate （54 .01% ） lymphoma patients ;Survivin positive reaction rate of inert lymphoma patients was also significantly lower than that of invasive lymphoma patients .The expression of survivin in non‐hodgkin＇s lymphoma tissue volume and age ,the immune phe‐notype ,clinical stage and clinical pathological indexes ,such as parts within the group no statistical difference ,lac‐tate dehydrogenase （LDH ） of 250 U/L or less patients with non‐hodgkin＇s lymphoma tissue survivin positive re‐sponse rate （23 .08% ） were significantly lower than that in LDH 〉 250 U/L patients （48 .65% ） .Survivin positive expression of 〉 25% of patients survival rate was significantly lower than Survivin positive expression of 〈 25% of the patients .Conclusion ：Survivin may be a tumor early diagnosis and prognosis prediction of new tumor markers .