老年舒张性心力衰竭患者NT-proBNP和CRP的变化及其临床意义±

Changes of NT-ProBNP and CRP in patients with senile diastolic heart failure and its clinical significance

目的 分析并评价老年舒张性心力衰竭患者N末端脑利钠肽原（NT-proBNP）和C-反应蛋白（CRP）的变化及其临床意义.方法 我院自2013年1月至2014年5月期间收治的65例舒张性心力衰竭患者,根据舒张性心力衰竭分级分成3组：弛缓受损组（27例）、假性正常充盈组（21例）和限制性充盈组（17例）;同时将心功能正常者作为对照组（24例）.对比分析各组受检者治疗前、后的血浆NT-proBNP和CRP值.结果 舒张性心力衰竭患者的NT-proBNP与CRP水平显著高于对照组,差异有统计学意义（P＜0.05）.舒张性心力衰竭患者假性正常充盈组的NT-proBNP水平（730.53±209.68）ng/L和CRP水平（4.05±2.23）ng/L均明显高于弛缓受损组的（359.92±100.65） ng/L和（2.28±1.22）ng/L（P＜0.05）,限制性充盈组的NT-proBNP水平（2262.03±1019.05）ng/L、CRP水平（8.42±3.13）ng/L明显高于弛缓受损组[（359.92± 100.65）ng/L、（2.28±1.22）ng/L]和假性正常化充盈组[（730.53±209.68）ng/L、（4.05±2.23）ng/L],差异有统计学意义（P＜0.05）.结论 舒张性心力衰竭患者NT-proBNP和CRP水平显著增高,且上升程度与舒张功能不全程度呈正比,两者对疗效评定及病情转归具有重要参考价值.

Objective To analyze and evaluate the change of NT-ProBNP and CRP in patients with se- nile diastolic heart failure and its clinical significance. Methods During 2013 January to 2014 May, a total of 65 cases of patients with diastolic heart failure, according to the classification of diastolic heart failure were divided in- to three groups： relaxation impairment group （27 cases ）, pseudonormal filling group （21 cases）, restrictive filling group（ 17 cases ）, and normal heart function as control group（24 cases）, comparative analysis of plasma NT-ProB- NP and CRP were values before and after treatment. Results The patients with diastolic heart failure NT-ProBNP and CRP levels were significantly higher than those in the control group （P〈0.05）, there were statistical significance. Diastolic heart failure in patients with pseudo normal filling. The level of NT-proBNP（730.53±209.68）ng/L and CRP levels （4.05±2.23）ng/L was obviously higher than that of relaxation impairment group （359.92±100.65） ng/L and （2.28± 1.22）ng/L （P〈0.05）, restrictive filling. The level of NT-proBNP （2262.03± 1019.05 ）ng/L and CRP level （8.42±3.13）ng/L was obviously higher than that of relaxation impairment group （359.92±100.65）ng/L, （2.28±l.22）ng/L and pseudonormal filling group （730.53：t=209.68）ng/L, （4.05±2.23）ng/L（P〈0.05）, there were statistical significance. Conclusion The levels of NT-ProBNP and CRP significantly increase in patients with di- astolic heart failure, and the increase extent is proportional to the degree of diastolic dysfunction, which has impor- tant reference value to assess efficacy outcome and disease.