睑板腺脂质在干眼症发病机制中的作用

Roles of meibomian lipids in dry eyes

干眼症是眼科常见病,根据病因可分为泪液分泌不足和泪液蒸发过强两种类型.位于泪膜最外层的脂质层由睑板腺分泌,具有维持泪膜稳定和防止泪液蒸发的作用.脂质层的组成成分以及组织结构对它的稳定性有很大影响,睑板腺功能障碍患者由于脂质层功能紊乱,造成泪膜稳定性下降及眼表的破坏,引起蒸发过强型干眼症.

Both aqueous tear deficiency and increasing evaporation lead to dry eye.The outmost part of the tear film is the lipid layer secreted from the meibomian glands.The meibomian lipids maintain the stability and prevent evaporation of the tear film.The composition and construction of lipid layer influence the stability of itself.In the patients with meibomian gland dysfunction （MGD）,the dysfunction of lipid layer leads to the reducing stability of tear film and destruction of ocular surface,and finally cause the over-evaporation dry eye.