益元生精汤治疗乳腺癌三苯氧胺治疗后类更年期综合征的临床观察

Yiyuan Shengjing Decoction Treat Similar Climacteric Syndrome of Breast Cancer after Treated with Tamoxifen

[目的]观察益元生精汤治疗乳腺癌三苯氧胺治疗后类更年期综合征的临床疗效。[方法]选取符合入选标准的乳腺癌患者60例,随机分为对照组30例和治疗组30例,对照组予三苯氧胺、谷维素治疗,治疗组予三苯氧胺、益元生精汤加减治疗。4周后评价疗效,比较两组治疗前后临床症状评分、激素水平及子宫内膜厚度,并计算临床缓解率。[结果]两组治疗后临床症状评分较治疗前均降低,差异有统计学意义(P<0.01);两组治疗后临床症状评分比较,治疗组明显低于对照组,差异有统计学意义(P<0.01);治疗组临床缓解率(治愈+显效+有效)达83.33%,而对照组临床缓解率为26.67%,差异有统计学意义(P<0.01);两组治疗前后生殖激素水平及子宫内膜厚度比较,差异无统计学意义(P>0.05)。[结论]益元生精汤治疗乳腺癌三苯氧胺治疗后类更年期综合征疗效显著,且不影响生殖激素水平及子宫内膜厚度。

Objective] To observe the clinical effect of Yiyuan Shengjing Decoction on similar climacteric syndrome of breast cancer after treated with tamoxifen. [Method] Choose 60 cases of breast cancer, randomly divide them into control group 30 cases and treatment group 30 cases, the control one were treated with tamoxifen and oryzanol, the treatment one, with tamoxifen and Yiyuan Shengjing Decoction. After 4w, evaluate the efficacy, compare their clinical symptoms score, hormone levels and endometrium thickness, and calculate the clinical relieving rate. [Result] After treatment, both groups clinical symptoms were relieved more than before treatment, with difference of statistical meaning; comparing on clinical symptoms scores, the treatment was much less than control one, with statistical meaning; on clinical relieving rates, the treatment group reached 83.33%, while 26.67% for control one, both had difference of statistical meaning. The comparison of reproductive hormone levels and endometrium thickness, the difference had no statistical meaning. [Conclusion] Yiyuan Shengjing Decoction treating breast cancer similar climacteric syndrome after treated with tamoxifen had marked cure effect, without influencing reproductive hormone level and endometrium thickness.