控制饮食联合有氧运动对非酒精性脂肪肝患者TNF-α、SREBP-1c水平的影响

Effect of diet control combined with aerobic exercise on TNF-α, SREBP-1c levels in patients with non-alcoholic fatty liver

目的探讨有氧运动与饮食控制对非酒精性脂肪肝患者血清TNF-α、SREBP-1c的影响。方法选择非酒精性脂肪肝患者60例为研究对象,根据干预方法不同分为运动组控制饮食组、联合组和对照组。比较干预前后患者TNF-α、SREBP-1c以及相关指标变化。结果联合组干预后腰臀比、TG、LDL/HDL、TNF-α、SREBP-1c、空腹胰岛素以及胰岛素抵抗显著改善(P<0.05或P<0.01)。TNF-α与HOMA-IR以及SREBP-1c具有显著正相关关系(P<0.05)。TNF-α及SREBP-1c与腰臀比、BMI以及TG具有正相关关系(P<0.05或P<0.01)。结论有氧运动联合控制饮食能够降低血清TNF-α及SREBP-1c水平。

Objective To discuss effect of diet control combined with aerobic exercise on TNF-α, SREBP-1c levels in patients with non-alcoholic fatty liver. Methods A total of 60 cases with non-alcoholic fatty liver were divided into exercise group, diet control group, combined group and control group. TNF-α, SREBP-1c and related indicators after intervention were analyzed. Results WHR, TG, LDL/HDL, TNF-α, SREBP-1c, FINA and HOMA-IR of combined group after intervention decreased apparently（P〈0.05 or P〈0.01）. TNF-α had a significant positive correlation with HOMA-IR and SREBP-1c（P〈0.05）. TNF-α and SREBP-1c had a significant positive correlation with WHR, BMI and TG（P〈0.01）. Conclusion Diet control combined with aerobic exercise can decrease TNF-α, SREBP-1c levels in patients with non-alcoholic fatty liver.