多重打击B细胞淋巴瘤的研究进展

Research progress of double-hit B cell lymphoma

多重打击B细胞淋巴瘤是指累及MYC/8q24的染色体畸变同时伴其他一种或多种染色体异常的B细胞淋巴瘤.其中,最早发现、最常见的重现染色体畸变为累及BCL2的t（14;18）（q32;q21）,还包括MYC^＋/BCL2^＋/BCL6^＋、MYC^＋/BCL6^＋、CCND1^＋/MYC^＋、BCL3^＋/MYC＋等.文章概述了介于弥漫大B细胞淋巴瘤和伯基特淋巴瘤之间未分类淋巴瘤中的多重打击B细胞淋巴瘤,内容包括流行病学、发病机制、临床特点及预后、病理特点及治疗进展.

Double-hit B cell lymphoma refers to a group of mature B cell lymphoma presented with MYC/8q24 rearrangement with one or more concurrent chromosomal translocations.The first and most common translocation ever found is t（14;18）（q32;q21） involving BCL2.Other breakpoint types include MYC^＋/ BCL2^＋/BCL6^＋,MYC^＋/BCL6^＋,CCND1^＋/MYC^＋,BCL3^＋/MYC^＋ et al.This article reviewed the recent publications about the double-hit B cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma.The contents of the review include epidemiology,clinical characteristics,histopathology,treatment,prognosis and some prospects for future work.