视神经脊髓炎年复发率及NMO-IgG阳性率影响因素的研究

Research of influence factors of yearly recurrence rate of neuromyelitis optica and positive rate of NMO-IgG

目的探讨视神经脊髓炎年复发率及NMO-Ig G阳性率的影响因素。方法选取2008年6月~2013年6月本院收治的视神经脊髓炎患者90例,通过6个项目（性别、发病年龄、病程、NMO-Ig G、脑干受累、单个脊髓病变最大长度值）对视神经脊髓炎年复发率的影响因素进行分析,根据随访调查结果分析视神经脊髓炎年复发率的相关因素。结果脑干受累患者视神经脊髓炎的年复发率明显高于脑干未受累患者（P〈0.05）,单个脊髓病变的最大长度值≥2 cm的NMO-Ig G阳性率明显高于单个脊髓病变的最大长度值〈2 cm（P〈0.05）;脑干受累情况是影响视神经脊髓炎年复发率的相关因素,单个脊髓病变的最大长度值是影响NMO-Ig G阳性率的相关因素。结论脑干受累是影响视神经脊髓炎年复发率的主要因素。血清NMO-Ig G阳性与单个脊髓病变最大长度值有关,测定该抗体可以判断视神经脊髓炎的病情活动情况。

Objective To discuss the influence factors of yearly recurrence rate of neuromyelitis optica and positive rate of NMO-Ig G. Methods 90 patients with neuromyelitis optica treated in our hospital were selected from June 2008 to June 2013,and the influence factors of yearly recurrence rate of neuromyelitis optica were analyzed through 6 projects（gender,age of onset,course of disease,NMO-Ig G,brain stem involvement,the maximum length value of a single spinal cord lesion）,and the related factors of yearly recurrence rate of neuromyelitis optica were analyzed according the followup and investigation results. Results Year recurrence rate of neuromyelitis optica in patients with brainstem involvement was significantly higher than that in patients with brainstem uninvolved（P〈0.05）.The positive rate of NMO-Ig G in maximum length value ≥2 cm of a single spinal cord lesion was significantly higher than that in maximum length value〈2 cm of a single spinal cord lesion（P〈0.05）;brainstem involvement was related factors of influencing the yearly recurrence rate of neuromyelitis optica,the maximum length value of a single spinal cord lesion was related factors of influencing the positive rate of NMO-Ig G. Conclusion Brain stem involvement are the main factors influencing the yearly recurrence of neuromyelitis optica.Positive NMO-Ig G of serum is associated with maximum length value of a single spinal cord lesion,and the determination of the antibody can judge the disease′ activity of neuromyelitis optica.