参麦注射液对体外循环患者的心肌保护作用研究

Research of Shenmai injection on myocardial protection in patients with extracorporeal circulation

目的研究参麦注射液在体外循环患者围术期的应用效果。方法选择在本院就诊的接受体外循环手术的患者92例,随机分为对照组和治疗组,每组46例。采用参麦注射液在围术期内对治疗组患者的心肌功能进行保护,对照组给予等量生理盐水,对比两组患者心肌功能指标恢复正常时间、临床手术治疗计划实施时间、手术前后心肌功能指标的变化、围术期不良反应发生率、体外循环手术治疗效果。结果治疗组患者心肌功能指标恢复正常时间[(4.13±0.87)d]和临床手术治疗计划实施时间[(7.59±1.64)d]明显短于对照组[(6.49±1.53)、(10.85±2.57)d](P<0.05)。治疗组总有效率(91.3%)明显高于对照组(71.8%)(P<0.05)。治疗组手术前后心肌功能指标的变化幅度明显小于对照组(P<0.05)。治疗组围术期不良反应发生率(6.5%)明显低于对照组(26.1%)(P<0.05)。结论参麦注射液应用于接受体外循环手术患者围术期的临床效果显著,可对患者心肌功能起积极的保护作用。

Objective To study application effect of Shenmai injection in perioperative patients with extracorporeal circulation. Methods 92 perioperative patients with extracorporeal circulation in our hospital were selected and randomly divided into control group and treatment group,each group of 46 cases.Shenmai injection was used in treatment group for myocardial function protection in perioperative period,normal saline was applied in control group.Myocardial function parameters returned to normal time,clinical surgery plans to implement the time,change the amplitude index of myocardial function before and after surgery,incidence rate of adverse reaction in perioperative period,cardiopulmonary bypass surgical treatment effect in two groups were compared. Results Myocardial function parameters returned to normal time[（4.13±0.87）d]and clinical surgery plans to implement the time[（7.59±1.64）d]in treatment group was significantly shorter than that in control group[（6.49±1.53）,（10.85±2.57）d]respectively（P〈0.05）.Total effective rate（91.3%）in treatment group was significantly higher than that in control group（71.8%）（P〈0.05）.Changes on amplitude index of myocardial function before and after surgery in treatment group was significantly litter than that in control group（P〈0.05）.Incidence rate of adverse reaction in perioperative period（6.5%）in treatment group was significantly lower than that in control group（26.1%）（P〈0.05）. Conclusion Shenmai injection applied in perioperative patients with extracorporeal circulation has a significant clinical effect,can play a positive protective role on myocardial function of patients.