窒息新生儿血糖变化的临床意义

The clinical significance of blood glucose changes in neonatal asphyxia

目的探讨窒息新生儿血糖变化的临床意义。方法回顾性分析2011年9月~2013年9月本科收治的110例新生儿窒息患儿,其中轻度窒息组患儿58例,重度窒息组患儿52例,比较两组患儿的血糖水平及恢复正常的构成比。结果轻度窒息组患儿的平均血糖值为（3.420±0.810）mmol/L,重度窒息患儿的平均血糖值为（8.170±2.526）mmol/L,两组差异有统计学意义（t=2.132,P〈0.05）。经过24 h治疗,轻度窒息组有50例（86.21%）患儿血糖恢复正常,重度窒息组有30例（57.69%）患儿血糖恢复正常,两组差异有统计学意义（χ^2=8.793,P〈0.05）。结论新生儿高血糖紊乱多发生于重度窒息患儿,轻度窒息患儿的空腹血糖水平较低;相对于轻度窒息患儿,重度窒息新生儿的血糖紊乱需要更长的时间进行正规治疗。临床医师应加强窒息新生儿的血糖监测,积极治疗原发病,及时纠正患儿血糖紊乱。

Objective To explore the clinical significance of blood glucose changes in neonatal asphyxia. Methods The datas of 110 children with neonatal asphyxia admitted to our department from September 2011 to September 2013 were retrospectively analyzed,58 cases were in mild asphyxia group,52 cases were in severe asphyxia group,the blood glucose levels and the proportions of its returned to normal were compared. Results The blood glucose level in mild asphyxia group was（3.420±0.810） mmol/L,the severe asphyxia group was（8.170±2.526） mmol/L,the difference was significant（t=2.132,P〈0.05）.After 24 hours treatment,there were 50 cases（86.21%） with blood glucose value returned to normal level in mild asphyxia group,30 cases（57.69%） severe asphyxia group,the difference was significant（χ2=8.793,P 〈0.05）.Conclusion Neonatal hyperglycemia disorder mostly occurres in children with severe asphyxia,fasting blood glucose level in children with mild asphyxia is lower;the regular treatment time of fasting blood glucose value returned to normal level in children with severe asphyxia is longer in comparison with that of children with mild asphyxia.Clinicians should strengthen blood glucose monitoring in neonatal asphyxia,actively treat the primary disease,promptly correct blood glucose disorder in children.