伴与不伴ADHD的多发性抽动患儿静态平衡功能研究

Stability index of TS children with attention deficit hyperactivity disorder

目的探讨伴与不伴注意缺陷多动障碍(ADHD)的多发性抽动障碍(TS)患儿静态平衡功能特点。方法采用美国《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准,并按照性别年龄配对的不伴ADHD的TS、共患ADHD的TS及正常儿童各39例为研究对象,应用静态平衡测试系统测定其稳定性系数(ST)。结果不伴ADHD的TS患儿与正常对照组在睁眼自然站立、闭眼自然站立、睁眼脚垫站立、闭眼脚垫站立等各姿势稳定系数比较,均无显著性差异(t值分别为0.533、0.721、1.535、0.324,均P>0.05);不伴ADHD的TS患儿与共患ADHD的TS组在睁眼自然站立、闭眼自然站立、睁眼脚垫站立、闭眼脚垫站立等各姿势的稳定系数比较,均具显著性差异(t值分别为14.829、15.090、15.763、15.789,均P<0.01);共患ADHD的TS患儿与正常对照组在睁眼自然站立、闭眼自然站立、睁眼脚垫站立、闭眼脚垫站立等各姿势稳定系数比较,均具显著性差异(t值分别为15.057、14.410、16.888、15.823,均P<0.01)。结论不伴ADHD的TS患儿与共患ADHD的TS患儿可能具有不同的神经病理机制。

Objective To explore the stability index of children with Tourette syndrome （ TS ） with or without attention deficit hyperactivity disorder （ ADHD） .Methods According to DSM-IV diagnostic criteria, the study involved TS children with ADHD, pure TS children and normal controls.Each group consisted of 39 subjects, and the groups were matched by gender and age.The stability indexes were measured by Tetrax balance system.Results Compared with the controls, pure TS children were not significantly different in stability indexes of normal position with eyes open, normal position with eyes closed, opened eyes on pillows and closed eyes on pillows （ t value was 0.533, 0.721, 1.535 and 0.324, respectively, all P〉0.05）.But they were significantly different from TS children with ADHD （t value was 14.829, 15.090, 15.763 and 15.7889, respectively, all P〈0.01）.The differences in the stability indexes of these gestures were also significant between TS children with ADHD and normal children （ t value was 15.057, 14.410, 16.888 and 15.823, respectively, all P〈0.01）.Conclusion The pathogenic mechanisms may be different between TS children with ADHD and those without ADHD.