急性冠状动脉综合征患者血清卵泡抑素样蛋白1水平与冠状动脉病变的相关性研究

Correlation of serum follistatin-like 1(FSTL1) protein level and coronary artery disease in patients with acute coronary syndrome (ACS)

目的:通过急性冠状动脉综合征(ACS)患者血清卵泡抑素样蛋白1(FSTL1)水平与冠状动脉病变相关性研究,探讨ACS患者血清FSTL1水平检测的临床意义。方法:选择ACS患者123例、稳定型心绞痛25例及对照组30例,采用酶联免疫吸附法测定血清FSTL1水平,采用目测法及定量冠状动脉造影分析法确定冠状动脉病变,应用SPSS17.0统计分析软件对结果进行分析处理,P<0.05为差异有统计学意义。结果:1 ACS各组中血清FSTL1水平明显均高于NC组和SAP组(P<0.01);2ACS患者血清FSTL1水平与冠脉病变范围呈相关趋势(P<0.01),血清FSTL1水平(经自然对数转化,LnFSTL1)在单支病变组(2.38±0.28)、双支病变组(2.43±0.26)、多支病变组(2.57±0.29)依次明显升高,各组间有统计学差异(F=5.25,P=0.007)。结论:1ACS患者血清FSTL1水平明显升高;2冠脉病变范围越大,血清FSTL1水平升高越明显,测定血清FSTL1水平对于ACS患者病情评估、预后评判可能有一定临床价值。

Objective：To observe the correlation of serum follistatin-like 1（FSTL1） protein level and coronary artery disease in patients with acute coronary syndrome（ACS）,and explore the clinical significance of serum FSTL1 level detection in patients with ACS.Methods：Among the total of 123 patients with ACS,25 patients with stable angina and the normal control group of 30 people were recruited. Serum FSTL1 level was measured by enzyme linked immunosorbent assay（ELISA）,and the severity of coronary artery stenosis was measured by visual method and quantitative coronary angiography. The SPSS 17.0 software was used for statistical analysis. P value〈0.05 was considered statistically significant. Results：Serum FSTL1 level in all groups with ACS were significantly higher than that in the NC group and the SAP group（P 〈 0.01）. Serum FSTL1 levels in patients with ACS were correlated the scope of coronary artery stenosis（P 〈 0.01）. Serum FSTL1 levels（calculation the natural logarithm of serum FSTL1 levels,LnFSTL1） in the single-vessel disease group（2.38 ± 0.28）,the double vessel disease group（2.43 ± 0.26）,the multivessel disease group（2.57 ± 0.29） were significantly increased in turn. Moreover,there was statistical difference in each group（F = 5.25,P = 0.007）. Conclusion：Serum FSTL1 levels in patients with ACS were significantly increased. The more serious the scope of coronary artery stenosis were,the higher serum FSTL1 levels elevated. Serum FSTL1 levels may have clinical value for the risk stratification and prognosis evaluation of ACS.