沙培林治疗乳腺癌根治术后腋窝积液的疗效观察

Effectiveness of Sapylin to Reduce Axillary effusion After radical correction in breast cancer

目的探讨局部应用沙培林治疗乳腺癌根治术后腋窝积液的疗效及安全性。方法选取2010年6月至2014年5月收治的579例乳腺癌患者,均接受了乳腺癌根治术或改良根治术。随机分为治疗组(312例)和对照组(287例),治疗组患者术中给予沙培林局部浸泡15min后,应用沙培林对淋巴结清扫区进行多点注射,并将沙培林药液浸泡过的少量可吸收止血海绵填塞于腋窝局部。对照组患者术中不使用沙培林,单纯生理盐水冲洗术野。比较两组患者术后的伤口疼痛平均持续时间、疼痛程度,腋窝引流量和引流管留置时间等。结果与对照组相比,治疗组的平均腋窝引流总量及术后引流管中位留置时间均明显低于对照组,差异有统计学意义(P<0.05)。而两组患者的术后伤口疼痛平均持续时间、疼痛程度以及术后发热发生率比较,差异无统计学意义(P>0.05)。结论乳腺癌患者术中局部应用沙培林能有效预防和治疗腋窝积液,缩短术后恢复时间。

Objective To describe a new method of the Sapylin powder to reduce Axillary effusion after radical correction in breast cancer.Methods Retrospective analysis of radical correction in breast cancer using or not using Sapylin was designed.From July 2010 to May 2014,a total of 579 patients were enrolled in this randomized study.Sapylin applied to the axillary fossa plus placement of closed suction drainage was used in 312 patients（the experimental group）;placement of closed suction drainage was used in 287 patients（the control group）.Results There were no significant differences in terms of the incidence of complications associated between the two groups.But the postoperative drainage magnitude and duration were significantly reduced in the experimental group.Conclusion Sapylin is a feasible and safe option for Axillary effusion After radical correction in breast cancer