特发性肺间质纤维化病因及诊断研究进展

Progress of study on etiology and diagnosis of idiopathic pulmonary fibrosis

特发性肺间质纤维化（IPF）是一种致死率高、与年龄相关、发病机制仍不清楚的肺部疾病。目前认为，年龄、烟草暴露、环境因素、病毒、遗传基因、慢性胃肠道酸或非酸性物质反流和吸入等危险因素参与了IPF的发生、发展。其临床的诊断主要依赖于高分辨率CT。IPF患者病情进展迅速，中位生存时间短，因此，深入了解IPF的病因及诊断对于患者的治疗和预后具有重要意义。

Idiopathic pulmonary fibrosis （IPF） is a highly lethal, age-related disease, in which pathogenesis remains unclear. Now, it is widely known that many risk factors are involved in the occurrence and development of IPF, including age, tobacco exposure, environmental factors, virus, genetic gene,chronic gastrointestinal acid or non acid reflux and inhalation. The clinical diagnosis of IPF mainly depends on the high resolution computed tomography. The IPF patients have rapidly deteriorated condition and short median survival time, therefore,it is of great significance to have an in-depth understanding of the pathogenesis and diagnose of IPF for the treatment and prognosis.