组蛋白乙酰化酶及去乙酰化酶与肺部疾病

Histone acetyltransferases/histone deacetylases with lung disease

组蛋白乙酰化酶与组蛋白去乙酰化酶町通过调节染色体结构而影响炎症基因的表达，亦可以通过调节非组蛋白的乙酰化和去乙酰化参与疾病的进程。在肺部疾病中，两者的相互平衡导致基因的异常表达或者相关调控因子的异常表达与肺癌、COPD、哮喘、激素抵抗等疾病密切相关，这也为各种组蛋白去乙酰化酶类药物应用于肺部疾病的治疗提供了理论基础。

Histone acetyltransferases （HATs） and histone deacetylases （HDACs） modify the expression of inflammation genes by regulating chromatin structure. Further more, they can also play an important role in disease development through modifing nonhistone proteins. In lung diseases,the balance between HATs and HDACs in gene levels and related regulators are associated with COPD,lung cancer, asthma, and corticosteroid resistance. These findings may provide theoretical basics for further development of HDACs targeting drugs in the treatment of lung diseases.