阿卡波糖对2型糖尿病患者TNF-α和IL-6的影响研究

Clinical study for the influence of acarbose on TNF-α and IL-6 on type 2 diabetes mellitus

目的 探讨阿卡波糖治疗2型糖尿病的疗效及对炎症因子的影响.方法 选取2012年1月至2013年12月收治的2型糖尿病患者共120例,按照随机数字表法分为观察组和对照组各60例.对照组给予饮食控制等非药物治疗,观察组在此基础上给予阿卡波糖治疗,疗程为12周.观察两组干预前后的空腹血糖、餐后2h血糖、糖化血红蛋白、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）炎症因子等指标.结果 干预前,两组的空腹血糖、餐后2h血糖与糖化血红蛋白比较差异无统计学意义（P＞0.05）;干预后两组患者以上观察指标均明显降低,观察组低于对照组,差异有统计学意义（P＜0.05）;干预前,两组的TNF-α、IL-6含量相当,差异无统计学意义（P＞0.05）;干预后,两组患者以上两个指标均显著下降,观察组显著低于对照组,差异均有统计学意义（P＜0.05）;两组均未出现严重不良反应.结论 阿卡波糖治疗2型糖尿病可以有效控制血糖,减轻胰岛素抵抗,是一种安全可靠的治疗方法.

Objective To study the the influence of acarbose on TNF-α and IL-6 in the treatment of type 2 diabetes mellitus.Methods One hundred and twenty patients with type 2 diabetes mellitus from January 2012 to December 2013 were selected and divided into observation group and control group randomly （60 cases in each group）.The control group were given diet control and other non drug therapy,observation group were given acarbose therapy for 12 weeks treatment.The fasting blood glucose,2 h postprandial blood glucose,HbA1c,TNF-α and IL-6 of the two groups were observed before and after intervention.Results Before the intervention,there was no statistical significance in the indicators above （P ＞ 0.05）.After intervention,all of the indexes were decreased,and the the change of observation group were more significant than that in the control group.The differences were significant （P ＜ 0.05）.Before the intervention,TNF-α and IL-6 content were the equivalent between the two groups,and there was no statistical difference （P ＞ 0.05）.After intervention,the two indexes were significantly decreased in both groups,and the observation group were significantly lower than that in the control group,and there were significant differences （all P ＜ 0.05）.There were no serious adverse reactions in both groups.Conclusions Type 2 diabetes mellitus treated by acarbose can effectively control blood glucose,and reduce insulin resistance,and it therefore is a safe and reliable treatment method.